Benjamin D Ortiz
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Explore the profile of Benjamin D Ortiz including associated specialties, affiliations and a list of published articles.
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10
Citations
103
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Recent Articles
1.
Kucerova-Levisohn M, Knirr S, Mejia R, Ortiz B
PLoS One
. 2015 Jul;
10(7):e0132856.
PMID: 26177549
Much progress has been made in understanding the important cis-mediated controls on mouse TCRα gene function, including identification of the Eα enhancer and TCRα locus control region (LCR). Nevertheless, previous...
2.
Kucerova-Levisohn M, Lovett J, Lahiji A, Holmes R, Zuniga-Pflucker J, Ortiz B
J Vis Exp
. 2014 Oct;
(92):e52119.
PMID: 25349888
The OP9/OP9-DL1 co-culture system has become a well-established method for deriving differentiated blood cell types from embryonic and hematopoietic progenitors of both mouse and human origin. It is now used...
3.
Lahiji A, Kucerova-Levisohn M, Holmes R, Zuniga-Pflucker J, Ortiz B
J Immunol Methods
. 2014 Apr;
407:135-45.
PMID: 24681242
Numerous locus control region (LCR) activities have been discovered in gene loci important to immune cell development and function. LCRs are a distinct class of cis-acting gene regulatory elements that...
4.
Lahiji A, Kucerova-Levisohn M, Lovett J, Holmes R, Zuniga-Pflucker J, Ortiz B
J Immunol
. 2013 May;
191(1):472-9.
PMID: 23720809
Locus control regions (LCRs) are cis-acting gene regulatory elements with the unique, integration site-independent ability to transfer the characteristics of their locus-of-origin's gene expression pattern to a linked transgene in...
5.
Arsov I, Adebayo A, Kucerova-Levisohn M, Haye J, MacNeil M, Papavasiliou F, et al.
J Immunol
. 2011 Jan;
186(4):2201-9.
PMID: 21239722
Autophagy is a highly regulated and evolutionarily conserved process of cellular self-digestion. Recent evidence suggests that this process plays an important role in regulating T cell homeostasis. In this study,...
6.
Knirr S, Gomos-Klein J, Andino B, Harrow F, Erhard K, Kovalovsky D, et al.
PLoS One
. 2010 Dec;
5(11):e15527.
PMID: 21124935
The molecular mechanisms regulating the activity of the TCRα gene are required for the production of the circulating T cell repertoire. Elements of the mouse TCRα locus control region (LCR)...
7.
Kovalovsky D, Pezzano M, Ortiz B, SantAngelo D
PLoS One
. 2010 Jan;
5(1):e8675.
PMID: 20072628
A complete understanding of negative selection has been elusive due to the rapid apoptosis and clearance of thymocytes in vivo. We report a TCR transgenic model in which expression of...
8.
Gomos-Klein J, Harrow F, Alarcon J, Ortiz B
J Immunol
. 2007 Jul;
179(2):1088-95.
PMID: 17617601
The mouse TCRalpha/TCRdelta/Dad1 gene locus bears a locus control region (LCR) that drives high-level, position-independent, thymic transgene expression in chromatin. It achieves this through DNA sequences that enhance transcription and...
9.
Harrow F, Ortiz B
J Immunol
. 2005 Nov;
175(10):6659-67.
PMID: 16272321
The molecular mechanisms ensuring the ordered expression of TCR genes are critical for proper T cell development. The mouse TCR alpha-chain gene locus contains a cis-acting locus control region (LCR)...
10.
Harrow F, Amuta J, Hutchinson S, Akwaa F, Ortiz B
J Biol Chem
. 2004 Feb;
279(17):17842-9.
PMID: 14966120
A locus control region (LCR) is a cis-acting gene-regulatory element capable of transferring the expression characteristics of its gene locus of origin to a linked transgene. Furthermore, it can do...