Derek B SantAngelo
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Explore the profile of Derek B SantAngelo including associated specialties, affiliations and a list of published articles.
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51
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1792
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Recent Articles
1.
Zakrzewski J, Suh D, Markley J, Smith O, King C, Goldberg G, et al.
Nat Biotechnol
. 2024 Mar;
42(4):674.
PMID: 38531977
No abstract available.
2.
Gilles A, Hu L, Virdis F, SantAngelo D, Dimitrova N, Hedrick J, et al.
J Immunol
. 2023 Oct;
211(11):1630-1642.
PMID: 37811896
Peptide loading of MHC class II (MHCII) molecules is facilitated by HLA-DM (DM), which catalyzes CLIP release, stabilizes empty MHCII, and edits the MHCII-bound peptide repertoire. HLA-DO (DO) binds to...
3.
Wang J, Adrianto I, Subedi K, Liu T, Wu X, Yi Q, et al.
Cell Discov
. 2023 Jun;
9(1):61.
PMID: 37336875
Unlike conventional αβT cells, invariant natural killer T (iNKT) cells complete their terminal differentiation to functional iNKT1/2/17 cells in the thymus. However, underlying molecular programs that guide iNKT subset differentiation...
4.
Campbell E, Dobkin J, Osorio L, Kolloli A, Ramasamy S, Kumar R, et al.
Vaccines (Basel)
. 2023 Apr;
11(4).
PMID: 37112744
The rapid development of several highly efficacious SARS-CoV-2 vaccines was an unprecedented scientific achievement that saved millions of lives. However, now that SARS-CoV-2 is transitioning to the endemic stage, there...
5.
Zhang Y, Bailey J, Xu E, Singh K, Lavaert M, Link V, et al.
Nat Immunol
. 2022 Nov;
23(12):1714-1725.
PMID: 36411380
Increasing evidence indicates close interaction between immune cells and the brain, revising the traditional view of the immune privilege of the brain. However, the specific mechanisms by which immune cells...
6.
Krzyzanowska A, Haynes Ii R, Kovalovsky D, Lin H, Osorio L, Edelblum K, et al.
Sci Immunol
. 2022 May;
7(71):eabf3717.
PMID: 35522722
The expression of BTB-ZF transcription factors such as ThPOK in CD4 T cells, Bcl6 in T follicular helper cells, and PLZF in natural killer T cells defines the fundamental nature...
7.
Darcy P, Denzin L, SantAngelo D
Sci Rep
. 2020 Mar;
10(1):3897.
PMID: 32127556
Co-expression of Yin Yang 1 (YY1) is required for the full function of the transcription factor, PLZF, which is essential for the development of natural killer T cell (NKT cell)...
8.
Newman J, Chesson C, Herzog N, Bommareddy P, Aspromonte S, Pepe R, et al.
Proc Natl Acad Sci U S A
. 2020 Jan;
117(2):1119-1128.
PMID: 31888983
Reprogramming the tumor microenvironment to increase immune-mediated responses is currently of intense interest. Patients with immune-infiltrated "hot" tumors demonstrate higher treatment response rates and improved survival. However, only the minority...
9.
Sheng H, Marrero I, Maricic I, Fanchiang S, Zhang S, SantAngelo D, et al.
J Immunol
. 2019 Sep;
203(8):2150-2162.
PMID: 31554695
Hepatic immune system is uniquely challenged to mount a controlled effector response to pathogens while maintaining tolerance to diet and microbial Ags. We have identified a novel population of innate-like,...
10.
Zhang S, Vieth J, Krzyzanowska A, Henry E, Denzin L, Siracusa M, et al.
J Immunol
. 2019 Aug;
203(5):1230-1241.
PMID: 31366712
Basophils are innate immune cells associated with type 2 immunity, allergic reactions, and host defense against parasite infections. In this study, we show that the transcription factor PLZF, which is...