Benjamin A Mayes
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Explore the profile of Benjamin A Mayes including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
19
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Recent Articles
1.
Cornelius P, Mayes B, Petersen J, Turnquist D, Dufour P, Dannenberg A, et al.
Mol Cancer Ther
. 2024 Mar;
23(5):595-605.
PMID: 38530115
Methionine aminopeptidase type 2 (METAP2) is a ubiquitous, evolutionarily conserved metalloprotease fundamental to protein biosynthesis which catalyzes removal of the N-terminal methionine residue from nascent polypeptides. METAP2 is an attractive...
2.
Dousson C, Alexandre F, Amador A, Bonaric S, Bot S, Caillet C, et al.
J Med Chem
. 2016 Jan;
59(5):1891-8.
PMID: 26804933
Here, we describe the design, synthesis, biological evaluation, and identification of a clinical candidate non-nucleoside reverse transcriptase inhibitors (NNRTIs) with a novel aryl-phospho-indole (APhI) scaffold. NNRTIs are recommended components of...
3.
Pan-Zhou X, Mayes B, Rashidzadeh H, Gasparac R, Smith S, Bhadresa S, et al.
Eur J Drug Metab Pharmacokinet
. 2015 Apr;
41(5):567-74.
PMID: 25898809
IDX184 is a phosphoramidate prodrug of 2'-methylguanosine-5'-monophosphate, developed to treat patients infected with hepatitis C virus. A mass balance study of radiolabeled IDX184 and pharmacokinetic studies of IDX184 in portal...
4.
Clarkson R, Komsta Z, Mayes B, Moussa A, Shelbourne M, Stewart A, et al.
J Org Chem
. 2015 Jan;
80(4):2198-215.
PMID: 25615008
Construction of protected 2,3-dideoxy-2-fluoro-2,3-endo-methylene-pentofuranoses from d-glyceraldehyde and 2,3-dideoxy-2-fluoro-3-C-hydroxymethyl-2,3-endo-methylene-pentofuranoses from d-isoascorbic acid, via Simmons-Smith-type stereoselective cyclopropanations on the respective fluoroallyl alcohols, is described. Synthesis of the corresponding conformationally locked sugar modified...
5.
Komsta Z, Mayes B, Moussa A, Shelbourne M, Stewart A, Tyrrell A, et al.
Org Lett
. 2014 Sep;
16(18):4878-80.
PMID: 25210994
The synthesis of the novel 2',3'-cyclopropane nucleoside 3'-deoxy-3'-C-hydroxymethyl-2',3'-methylene-uridine is described. Stereoselective construction of the cyclopropane ring was achieved via Simmons-Smith cyclopropanation of a benzyl protected silyl enol ether, which was...
6.
Chapron C, Glen R, La Colla M, Mayes B, McCarville J, Moore S, et al.
Bioorg Med Chem Lett
. 2014 May;
24(12):2699-702.
PMID: 24815510
The synthesis of 2'-O,4'-C-methylene-bridged bicyclic guanine ribonucleosides bearing 2'-C-methyl or 5'-C-methyl modifications is described. Key to the successful installation of the methyl functionality in both cases was the use of...
7.
Mayes B, McGarry P, Moussa A, Watkin D
Acta Crystallogr Sect E Struct Rep Online
. 2011 Jan;
64(Pt 7):o1355.
PMID: 21202974
Chlorination of 3-fluoro-2-methyl-aniline with N-chloro-succinimide gave one major regioisomer whose structure was determined by X-ray crystallography. The product was found to have cocrystallized with succinimide, giving the title compound, C(7)H(7)ClFN·C(4)H(5)NO(2)....