Benjamin A Fensterheim
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Explore the profile of Benjamin A Fensterheim including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
390
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Recent Articles
1.
McBride M, Stothers C, Fensterheim B, Caja K, Owen A, Hernandez A, et al.
J Leukoc Biol
. 2023 Oct;
115(2):358-373.
PMID: 37793181
Exposure to pathogen-associated molecular patterns (PAMPs) induces an augmented, broad-spectrum antimicrobial response to subsequent infection, a phenomenon termed innate immune memory. This study examined the effects of treatment with β-glucan,...
2.
Sucre J, Vickers K, Benjamin J, Plosa E, Jetter C, Cutrone A, et al.
Am J Respir Crit Care Med
. 2020 Feb;
201(10):1249-1262.
PMID: 32023086
Bronchopulmonary dysplasia (BPD) is a leading complication of preterm birth that affects infants born in the saccular stage of lung development at <32 weeks of gestation. Although the mechanisms driving...
3.
Hernandez A, Luan L, Stothers C, Patil N, Fults J, Fensterheim B, et al.
Crit Care Med
. 2019 Oct;
47(11):e930-e938.
PMID: 31567352
Objectives: To determine whether synthetic phosphorylated hexa-acyl disaccharides provide antimicrobial protection in clinically relevant models of bacterial infection. Design: Laboratory study. Setting: University laboratory. Subjects: BALB/c, C57BL/10J, and C57BL/10ScNJ mice....
4.
Fensterheim B, Young J, Luan L, Kleinbard R, Stothers C, Patil N, et al.
J Immunol
. 2018 Apr;
200(11):3777-3789.
PMID: 29686054
Monophosphoryl lipid A (MPLA) is a clinically used TLR4 agonist that has been found to drive nonspecific resistance to infection for up to 2 wk. However, the molecular mechanisms conferring...
5.
Fensterheim B, Guo Y, Sherwood E, Bohannon J
J Immunol
. 2017 Mar;
198(8):3264-3273.
PMID: 28275139
The magnitude of the LPS-elicited cytokine response is commonly used to assess immune function in critically ill patients. A suppressed response, known as endotoxin tolerance, is associated with worse outcomes,...
6.
Luan L, Patil N, Guo Y, Hernandez A, Bohannon J, Fensterheim B, et al.
Sci Rep
. 2017 Jan;
7:40050.
PMID: 28053314
Monophosphoryl lipid A (MPLA), a less toxic derivative of lipopolysaccharide (LPS), is employed as a vaccine adjuvant and is under investigation as a non-specific immunomodulator. However, the differential response of...
7.
Guo Y, Luan L, Patil N, Wang J, Bohannon J, Rabacal W, et al.
J Immunol
. 2016 Dec;
198(3):1320-1333.
PMID: 28031340
Interleukin 15 is essential for the development and differentiation of NK and memory CD8 (mCD8) T cells. Our laboratory previously showed that NK and CD8 T lymphocytes facilitate the pathobiology...
8.
Hernandez A, Bohannon J, Luan L, Fensterheim B, Guo Y, Patil N, et al.
J Leukoc Biol
. 2016 Jun;
100(6):1311-1322.
PMID: 27354411
Treatment with the TLR4 agonist MPLA augments innate resistance to common bacterial pathogens. However, the cellular and molecular mechanisms by which MPLA augments innate immunocyte functions are not well characterized....
9.
Nyhoff L, Barron B, Johnson E, Bonami R, Maseda D, Fensterheim B, et al.
Arthritis Rheumatol
. 2016 Mar;
68(8):1856-68.
PMID: 26945549
Objective: Bruton's tyrosine kinase (BTK) is a B cell signaling protein that also contributes to innate immunity. BTK inhibitors prevent autoimmune arthritis but have off-target effects, and the mechanisms of...
10.
Stark R, Choi H, Koch S, Fensterheim B, Lamb F, Sherwood E
Clin Sci (Lond)
. 2015 Dec;
130(6):451-61.
PMID: 26669797
Prior exposure to lipopolysaccharide (LPS) produces a reduced or "tolerant" inflammatory response to subsequent challenges with LPS, however the potent pro-inflammatory effects of LPS limit its clinical benefit. The adjuvant...