Behnam Javidfar
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Explore the profile of Behnam Javidfar including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
479
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Recent Articles
11.
Fullard J, Lee H, Voloudakis G, Suo S, Javidfar B, Shao Z, et al.
Genome Med
. 2021 Jul;
13(1):118.
PMID: 34281603
Background: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has been associated with neurological and neuropsychiatric illness in many individuals. We sought to further...
12.
Espeso-Gil S, Halene T, Bendl J, Kassim B, Ben Hutta G, Iskhakova M, et al.
Genome Med
. 2020 Feb;
12(1):19.
PMID: 32075678
Background: Midbrain dopaminergic neurons (MDN) represent 0.0005% of the brain's neuronal population and mediate cognition, food intake, and metabolism. MDN are also posited to underlay the neurobiological dysfunction of schizophrenia...
13.
Rajarajan P, Borrman T, Liao W, Schrode N, Flaherty E, Casino C, et al.
Science
. 2018 Dec;
362(6420).
PMID: 30545851
To explore the developmental reorganization of the three-dimensional genome of the brain in the context of neuropsychiatric disease, we monitored chromosomal conformations in differentiating neural progenitor cells. Neuronal and glial...
14.
Javidfar B, Park R, Kassim B, Bicks L, Akbarian S
Am J Med Genet B Neuropsychiatr Genet
. 2017 Jul;
174(6):631-640.
PMID: 28699694
Large-scale consortia including the Psychiatric Genomics Consortium, the Common Minds Consortium, BrainSeq and PsychENCODE, and many other studies taken together provide increasingly detailed insights into the genetic and epigenetic risk...
15.
Jiang Y, Loh Y, Rajarajan P, Hirayama T, Liao W, Kassim B, et al.
Nat Genet
. 2017 Jul;
49(8):1239-1250.
PMID: 28671686
We report locus-specific disintegration of megabase-scale chromosomal conformations in brain after neuronal ablation of Setdb1 (also known as Kmt1e; encodes a histone H3 lysine 9 methyltransferase), including a large topologically...
16.
Walsh R, Shen E, Bagot R, Anselmo A, Jiang Y, Javidfar B, et al.
Nat Commun
. 2017 May;
8:15142.
PMID: 28485378
PHF8 is a histone demethylase with specificity for repressive modifications. While mutations of PHF8 have been associated with cognitive defects and cleft lip/palate, its role in mammalian development and physiology...
17.
Mitchell A, Javidfar B, Bicks L, Neve R, Garbett K, Lander S, et al.
Nat Commun
. 2016 Sep;
7:12743.
PMID: 27597321
Neuronal epigenomes, including chromosomal loopings moving distal cis-regulatory elements into proximity of target genes, could serve as molecular proxy linking present-day-behaviour to past exposures. However, longitudinal assessment of chromatin state...
18.
Shen E, Jiang Y, Javidfar B, Kassim B, Loh Y, Ma Q, et al.
Neuropsychopharmacology
. 2016 Aug;
41(13):3103-3113.
PMID: 27485686
Lysine (K) methyltransferase 2a (Kmt2a) and other regulators of H3 lysine 4 methylation, a histone modification enriched at promoters and enhancers, are widely expressed throughout the brain, but molecular and...
19.
Halene T, Kozlenkov A, Jiang Y, Mitchell A, Javidfar B, Dincer A, et al.
Schizophr Res
. 2016 Jan;
170(2-3):235-44.
PMID: 26776227
Increased neuronal densities in subcortical white matter have been reported for some cases with schizophrenia. The underlying cellular and molecular mechanisms remain unresolved. We exposed 26 young adult macaque monkeys...
20.
Jakovcevski M, Ruan H, Shen E, Dincer A, Javidfar B, Ma Q, et al.
J Neurosci
. 2015 Apr;
35(13):5097-108.
PMID: 25834037
Neuronal histone H3-lysine 4 methylation landscapes are defined by sharp peaks at gene promoters and other cis-regulatory sequences, but molecular and cellular phenotypes after neuron-specific deletion of H3K4 methyl-regulators remain...