Beatrice Haimovich
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Explore the profile of Beatrice Haimovich including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
494
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Recent Articles
1.
Toll-Like Receptor 4 Induction During Renal Ischemia Correlates with Serum Creatinine in a Pig Model
Steinberg R, Johnson B, Sorkin I, Garbens A, Zhang Z, Haimovich B, et al.
J Endourol
. 2023 May;
37(7):828-833.
PMID: 37221836
To determine whether toll-like receptor 4 (TLR4), a mediator of organ ischemia-reperfusion injury, is overexpressed during warm ischemia in a porcine solitary kidney model, and whether its expression correlates with...
2.
Zhang Z, Amorosa L, Petrova A, Coyle S, Macor M, Nair M, et al.
Sci Rep
. 2019 May;
9(1):7020.
PMID: 31065010
TLR4 is implicated in diseases associated with chronic low-grade inflammation, yet homeostatic signaling mechanisms that prevent and/or are affected by chronic TLR4 activation are largely uncharacterized. We recently reported that...
3.
Zhang Z, Amorosa L, Coyle S, Macor M, Birnbaum M, Lee L, et al.
Diabetes
. 2016 May;
65(8):2224-34.
PMID: 27207509
Leukocyte signaling in patients with systemic insulin resistance is largely unexplored. We recently discovered the presence of multiple Toll-like receptor 4 (TLR4) signaling intermediates in leukocytes from patients with type...
4.
Zhang Z, Haimovich B, Kwon Y, Lu T, Fyfe-Kirschner B, Olweny E
PLoS One
. 2016 May;
11(5):e0154708.
PMID: 27149666
Purpose: Ischemia/reperfusion (I/R) during partial nephrectomy (PN) contributes to acute kidney injury (AKI), which is inaccurately assessed using existent clinical markers of renal function. We evaluated I/R-related changes in expression...
5.
Zhang Z, Amorosa L, Coyle S, Macor M, Lubitz S, Carson J, et al.
J Immunol
. 2015 Aug;
195(5):2452-60.
PMID: 26232429
LPS-induced TLR4 activation alters cellular bioenergetics and triggers proteolytic cleavage of AMPKα and HIF-1α expression in leukocytes. In human leukocytes, and more specifically neutrophils, AMPKα cleavage yields 55- and 35-kDa...
6.
Kamisoglu K, Haimovich B, Calvano S, Coyle S, Corbett S, Langley R, et al.
Crit Care
. 2015 Apr;
19:71.
PMID: 25887472
Introduction: Two recent, independent, studies conducted novel metabolomics analyses relevant to human sepsis progression; one was a human model of endotoxin (lipopolysaccharide (LPS)) challenge (experimental endotoxemia) and the other was...
7.
Haimovich B, Zhang Z, Calvano J, Calvano S, Kumar A, Macor M, et al.
Ann Surg
. 2013 Jul;
259(5):999-1006.
PMID: 23817504
Objective: The Toll-like receptor 4 (TLR4) ligand endotoxin triggers robust systemic inflammatory responses in humans at doses equal to or greater than 1 ng/kg. In this study, we tested the...
8.
Zhang Z, Lowry S, Guarente L, Haimovich B
J Biol Chem
. 2010 Oct;
285(53):41391-401.
PMID: 20966076
Endotoxin is a potent inducer of systemic inflammatory responses in human and rodents. Here, we show that in vivo endotoxin triggers a rapid and transient decline in ATP concentration in...
9.
Haimovich B, Reddell M, Calvano J, Calvano S, Macor M, Coyle S, et al.
Crit Care
. 2010 Oct;
14(5):R177.
PMID: 20929567
Introduction: An endotoxin challenge, sepsis, and injury/trauma, trigger significant changes in human peripheral blood leukocytes (PBL) gene expression. In this study, we have sought to test the hypothesis that the...
10.
Haimovich B, Calvano J, Haimovich A, Calvano S, Coyle S, Lowry S
Crit Care Med
. 2010 Jan;
38(3):751-8.
PMID: 20081528
Objectives: The intravenous administration of a bolus dose of endotoxin to healthy human subjects triggers acute systemic inflammatory responses that include cytokine production and dynamic changes in gene expression in...