Steve E Calvano
Overview
Explore the profile of Steve E Calvano including associated specialties, affiliations and a list of published articles.
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53
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3733
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Recent Articles
1.
Kamisoglu K, Haimovich B, Calvano S, Coyle S, Corbett S, Langley R, et al.
Crit Care
. 2015 Apr;
19:71.
PMID: 25887472
Introduction: Two recent, independent, studies conducted novel metabolomics analyses relevant to human sepsis progression; one was a human model of endotoxin (lipopolysaccharide (LPS)) challenge (experimental endotoxemia) and the other was...
2.
Herlitz G, Arlow R, Cheung N, Coyle S, Griffel B, Macor M, et al.
Shock
. 2014 Dec;
43(2):133-9.
PMID: 25526373
Introduction: Human injury or infection induces systemic inflammation with characteristic neuroendocrine responses. Fluctuations in autonomic function during inflammation are reflected by beat-to-beat variation in heart rate, termed heart rate variability...
3.
Kamisoglu K, Calvano S, Coyle S, Corbett S, Androulakis I
Shock
. 2014 Jul;
42(6):499-508.
PMID: 25061728
In this meta-study, we aimed to integrate biological insights gained from two levels of -omics analyses on the response to systemic inflammation induced by lipopolysaccharide in humans. We characterized the...
4.
Scheff J, Griffel B, Corbett S, Calvano S, Androulakis I
Math Biosci
. 2014 Apr;
252:36-44.
PMID: 24680646
Analysis of heart rate variability (HRV) is a promising diagnostic technique due to the noninvasive nature of the measurements involved and established correlations with disease severity, particularly in inflammation-linked disorders....
5.
Kosmides A, Kamisoglu K, Calvano S, Corbett S, Androulakis I
Crit Rev Biomed Eng
. 2014 Mar;
41(3):205-21.
PMID: 24579644
Systems biology has primarily focused on studying genomics, transcriptomics, and proteomics and their dynamic interactions. These, however, represent only the potential for a biological outcome since the ultimate phenotype at...
6.
Kamisoglu K, Sleight K, Nguyen T, Calvano S, Coyle S, Corbett S, et al.
Innate Immun
. 2013 Nov;
20(7):774-84.
PMID: 24217219
Severe traumas are associated with hypercortisolemia due to both disruption of cortisol secretion rhythm and increase in its total concentration. Understanding the effects of altered cortisol levels and rhythms on...
7.
Kamisoglu K, Sleight K, Calvano S, Coyle S, Corbett S, Androulakis I
Shock
. 2013 Oct;
40(6):519-26.
PMID: 24089011
Endotoxemia induced by the administration of low-dose lipopolysaccharide (LPS) to healthy human volunteers is a well-established experimental protocol and has served as a reproducible platform for investigating the responses to...
8.
Scheff J, Calvano S, Androulakis I
J Theor Biol
. 2013 Aug;
338:9-15.
PMID: 23973206
The human body can be viewed as a dynamical system, with physiological states such as health and disease broadly representing steady states. From this perspective, and given inter- and intra-individual...
9.
Haimovich B, Zhang Z, Calvano J, Calvano S, Kumar A, Macor M, et al.
Ann Surg
. 2013 Jul;
259(5):999-1006.
PMID: 23817504
Objective: The Toll-like receptor 4 (TLR4) ligand endotoxin triggers robust systemic inflammatory responses in humans at doses equal to or greater than 1 ng/kg. In this study, we tested the...
10.
Seok J, Warren H, Cuenca A, Mindrinos M, Baker H, Xu W, et al.
Proc Natl Acad Sci U S A
. 2013 Feb;
110(9):3507-12.
PMID: 23401516
A cornerstone of modern biomedical research is the use of mouse models to explore basic pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-go decisions to carry new...