Bauer L LeSavage
Overview
Explore the profile of Bauer L LeSavage including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
17
Citations
541
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
LeSavage B, Zhang D, Huerta-Lopez C, Gilchrist A, Krajina B, Karlsson K, et al.
Nat Mater
. 2024 Jul;
23(8):1138-1149.
PMID: 38965405
Pancreatic ductal adenocarcinoma (PDAC) is characterized by its fibrotic and stiff extracellular matrix. However, how the altered cell/extracellular-matrix signalling contributes to the PDAC tumour phenotype has been difficult to dissect....
2.
Roth J, Huang M, Navarro R, Akram J, LeSavage B, Heilshorn S
Sci Adv
. 2023 Oct;
9(42):eadh8313.
PMID: 37862423
Human-induced pluripotent stem cells (hiPSCs) have emerged as a promising in vitro model system for studying neurodevelopment. However, current models remain limited in their ability to incorporate tunable biomechanical signaling...
3.
Shayan M, Huang M, Navarro R, Chiang G, Hu C, Oropeza B, et al.
J Biomed Mater Res A
. 2023 Mar;
111(7):896-909.
PMID: 36861665
Mechanical cues from the extracellular matrix (ECM) regulate vascular endothelial cell (EC) morphology and function. Since naturally derived ECMs are viscoelastic, cells respond to viscoelastic matrices that exhibit stress relaxation,...
4.
Lee C, Hunt D, Roth J, Chiu C, Suhar R, LeSavage B, et al.
Biomaterials
. 2022 Nov;
291:121864.
PMID: 36343608
Exosome-based regenerative therapies are potentially easier to manufacture and safer to apply compared to cell-based therapies. However, many questions remain about how to bio-manufacture reproducible and potent exosomes using animal-free...
5.
Qian J, LeSavage B, Hubka K, Ma C, Natarajan S, Eggold J, et al.
J Clin Invest
. 2021 Aug;
131(16).
PMID: 34396988
Ovarian cancer is the leading cause of gynecological malignancy-related deaths, due to its widespread intraperitoneal metastases and acquired chemoresistance. Mesothelial cells are an important cellular component of the ovarian cancer...
6.
LeSavage B, Suhar R, Broguiere N, Lutolf M, Heilshorn S
Nat Mater
. 2021 Aug;
21(2):143-159.
PMID: 34385685
Organotypic models of patient-specific tumours are revolutionizing our understanding of cancer heterogeneity and its implications for personalized medicine. These advancements are, in part, attributed to the ability of organoid models...
7.
Hunt D, Klett K, Mascharak S, Wang H, Gong D, Lou J, et al.
Adv Sci (Weinh)
. 2021 May;
8(10):2004705.
PMID: 34026461
Human intestinal organoids from primary human tissues have the potential to revolutionize personalized medicine and preclinical gastrointestinal disease models. A tunable, fully defined, designer matrix, termed hyaluronan elastin-like protein (HELP)...
8.
Krajina B, LeSavage B, Roth J, Zhu A, Cai P, Spakowitz A, et al.
Sci Adv
. 2021 Feb;
7(8).
PMID: 33597244
Living tissues embody a unique class of hybrid materials in which active and thermal forces are inextricably linked. Mechanical characterization of tissues demands descriptors that respect this hybrid nature. In...
9.
10.
Madl C, LeSavage B, Khariton M, Heilshorn S
Adv Healthc Mater
. 2020 Aug;
9(18):e2000754.
PMID: 32743903
Neural progenitor cells (NPCs) are promising therapeutic candidates for nervous system regeneration. Significant efforts focus on developing hydrogel-based approaches to facilitate the clinical translation of NPCs, from scalable platforms for...