Bastian Brauning
Overview
Explore the profile of Bastian Brauning including associated specialties, affiliations and a list of published articles.
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10
Citations
203
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Recent Articles
1.
Botsch J, Junker R, Sorgenfrei M, Ogger P, Stier L, von Gronau S, et al.
Nat Commun
. 2024 Jan;
15(1):410.
PMID: 38195637
Transmembrane E3 ligases play crucial roles in homeostasis. Much protein and organelle quality control, and metabolic regulation, are determined by ER-resident MARCH6 E3 ligases, including Doa10 in yeast. Here, we...
2.
Gonzalez A, Covarrubias-Pinto A, Bhaskara R, Glogger M, Kuncha S, Xavier A, et al.
Nature
. 2023 May;
618(7964):394-401.
PMID: 37225996
The endoplasmic reticulum (ER) undergoes continuous remodelling via a selective autophagy pathway, known as ER-phagy. ER-phagy receptors have a central role in this process, but the regulatory mechanism remains largely...
3.
Miller-Vedam L, Brauning B, Popova K, Schirle Oakdale N, Bonnar J, Prabu J, et al.
Elife
. 2020 Nov;
9.
PMID: 33236988
Membrane protein biogenesis in the endoplasmic reticulum (ER) is complex and failure-prone. The ER membrane protein complex (EMC), comprising eight conserved subunits, has emerged as a central player in this...
4.
Vieweg S, Mulholland K, Brauning B, Kachariya N, Lai Y, Toth R, et al.
Biochem J
. 2020 Apr;
477(9):1651-1668.
PMID: 32227113
Loss of function mutations in the PTEN-induced kinase 1 (PINK1) kinase are causal for autosomal recessive Parkinson's disease (PD) whilst gain of function mutations in the LRRK2 kinase cause autosomal...
5.
Brauning B, Groll M
Toxins (Basel)
. 2018 Aug;
10(9).
PMID: 30142951
Recent technological advances have seen increasing numbers of complex structures from diverse pore-forming toxins (PFT). The ClyA family of α-PFTs comprises a broad variety of assemblies including single-, two- and...
6.
Golovenko D, Brauning B, Vyas P, Haran T, Rozenberg H, Shakked Z
Structure
. 2018 Jul;
26(9):1237-1250.e6.
PMID: 30057026
The tumor suppressor p53 acts as a transcription factor recognizing diverse DNA response elements (REs). Previous structural studies of p53-DNA complexes revealed non-canonical Hoogsteen geometry of A/T base pairs at...
7.
Brauning B, Bertosin E, Praetorius F, Ihling C, Schatt A, Adler A, et al.
Nat Commun
. 2018 May;
9(1):1806.
PMID: 29728606
Pore-forming toxins (PFT) are virulence factors that transform from soluble to membrane-bound states. The Yersinia YaxAB system represents a family of binary α-PFTs with orthologues in human, insect, and plant...
8.
Wachtel R, Brauning B, Mader S, Ecker F, Kaila V, Groll M, et al.
Nat Commun
. 2018 Jan;
9(1):44.
PMID: 29298974
Salmonella infections require the delivery of bacterial effectors into the host cell that alter the regulation of host defense mechanisms. The secreted cysteine protease GtgE from S. Typhimurium manipulates vesicular...
9.
Solomon H, Brauning B, Fainer I, Ben-Nissan G, Rabani S, Goldfinger N, et al.
Cell Death Differ
. 2017 Sep;
24(12):2187-2198.
PMID: 28885617
The tumor suppressor p53 is a transcription factor that regulates the expression of a range of target genes in response to cellular stress. Adding to the complexity of understanding its...
10.
Kolek S, Brauning B, Stewart P
Acta Crystallogr F Struct Biol Commun
. 2016 Apr;
72(Pt 4):307-12.
PMID: 27050265
Random microseed matrix screening (rMMS), in which seed crystals are added to random crystallization screens, is an important breakthrough in soluble protein crystallization that increases the number of crystallization hits...