Bassem H Naguib
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Explore the profile of Bassem H Naguib including associated specialties, affiliations and a list of published articles.
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12
Citations
50
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Recent Articles
1.
Shaalan M, Osman E, Attia Y, Hammam O, George R, Naguib B
ACS Omega
. 2024 Sep;
9(35):37310-37329.
PMID: 39246493
A series of novel 3,6-disubstituted pyridazine derivatives were designed, synthesized, and biologically evaluated as preclinical anticancer candidates. Compound exhibited the highest growth inhibition against most of the NCI-60 cancer cell...
2.
Naguib B, Elsebaie H, Nafie M, Mohamady S, Albujuq N, Samir Ayed A, et al.
Bioorg Chem
. 2024 Aug;
151:107682.
PMID: 39137597
c-MET and STAT-3 are significant targets for cancer treatments. Here, we describe a class of very effective dual STAT-3 and c-MET inhibitors with coumarin-based thiazoles (3a-o) as its scaffold. Spectroscopic...
3.
El-Gaby M, Reheim M, Akrim Z, Naguib B, Saleh N, El-Adasy A, et al.
Drug Dev Res
. 2024 Feb;
85(1):e22143.
PMID: 38349267
The effectiveness of a new series of thiopyrimidine and thiourea containing sulfonamides moieties was tested on HCT-116, MCF-7, HepG2, and A549. HepG2 cell line was the one that all the...
4.
Mohamady S, Khalil A, Naguib B, Nafie M, Tawfik H, Shaldam M
Bioorg Chem
. 2023 Nov;
143:106988.
PMID: 37995644
For the horseshoe tactic to succeed in inhibiting c-Met and Pim-1, the nicotinonitrile derivatives (2a-n) were produced in high quantities by coupling acetyl phenylpyrazole (1) with the proper aldehydes and...
5.
Mohamady S, Gibriel A, Ahmed M, Hendy M, Naguib B
Bioorg Chem
. 2020 Feb;
96:103641.
PMID: 32032844
A novel synthetic approach was developed for the synthesis of 3-hydrazinotriazolothiadiazines in just one step from Purpald and phenacyl bromides. They were then selectively tethered to naphthoquinone fragments through hydrazine...
6.
Hendy M, Ali A, Ahmed L, Hossam R, Mostafa A, Elmazar M, et al.
Eur J Med Chem
. 2019 Feb;
166:281-290.
PMID: 30731397
Offering novel scaffolds targeting estrogen receptor creates huge necessity to overcome the evolving resistance developed by tumors. Structure-based drug design coupled with ring opening strategy of the steroids skeleton revealed...
7.
Kandeel M, Kamal A, Naguib B, Hassan M
Anticancer Agents Med Chem
. 2019 Jan;
18(8):1208-1217.
PMID: 30672411
Aims: Tyrosine kinases and topoisomerase I are common target enzymes for the majority of the anticancer agents. In contrast to quinazolines and quinolines, kinase inhibitors and topoisomerase inhibitors incorporating cinnoline...
8.
El-Nassan H, Naguib B, Beshay E
J Enzyme Inhib Med Chem
. 2017 Nov;
33(1):58-66.
PMID: 29161928
Three series of 2-arylpyridothieno[3,2-d]pyrimidin-4-ones 3a-j, pyridothienotriazolopyrimidines 6-8 and 4-imino-pyridothieno[3,2-d]pyrimidines 9a,b were prepared to improve the pim-1 inhibitory activity of the previously reported 2-arylpyridothieno[3,2-d]pyrimidin-4-ones. All the test compounds showed highly potent...
9.
Naguib B, El-Nassan H, Abdelghany T
J Enzyme Inhib Med Chem
. 2017 Jan;
32(1):457-467.
PMID: 28097906
Four series of pyridothienopyrimidin-4-one derivatives were designed and prepared to improve the pim-1 inhibitory activity of the previously reported thieno[2,3-b]pyridines. Significant improvement in the pim-1 inhibition and cytotoxic activity was...
10.
Naguib B, El-Nassan H
J Enzyme Inhib Med Chem
. 2016 Aug;
31(6):1718-25.
PMID: 27541740
Three series of 5-bromo-thieno[2,3-b]pyridines bearing amide or benzoyl groups at position 2 were prepared as pim-1 inhibitors. All the prepared compounds were tested for their pim-1 enzyme inhibitory activity. Two...