Bas Molenaar
Overview
Explore the profile of Bas Molenaar including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
12
Citations
431
Followers
0
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Recent Articles
1.
Gladka M, Kohela A, de Leeuw A, Molenaar B, Versteeg D, Kooijman L, et al.
Cardiovasc Res
. 2024 Sep;
120(15):1869-1883.
PMID: 39308239
Aims: Intracellular calcium (Ca2+) overload is known to play a critical role in the development of cardiac dysfunction. Despite the remarkable improvement in managing the progression of heart disease, developing...
2.
Gladka M, Johansen A, van Kampen S, Peters M, Molenaar B, Versteeg D, et al.
Cardiovasc Res
. 2022 Sep;
119(3):802-812.
PMID: 36125329
Aims: The adult mammalian heart is a post-mitotic organ. Even in response to necrotic injuries, where regeneration would be essential to reinstate cardiac structure and function, only a minor percentage...
3.
Wehrens M, de Leeuw A, Wright-Clark M, Eding J, Boogerd C, Molenaar B, et al.
Cell Rep
. 2022 May;
39(6):110809.
PMID: 35545053
Hypertrophic cardiomyopathy (HCM) is a genetic heart disease that is characterized by unexplained segmental hypertrophy that is usually most pronounced in the septum. While sarcomeric gene mutations are often the...
4.
Kohela A, van Kampen S, Moens T, Wehrens M, Molenaar B, Boogerd C, et al.
Sci Transl Med
. 2021 Sep;
13(612):eabf2750.
PMID: 34550725
Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder often caused by pathogenic variants in desmosomal genes and characterized by progressive fibrotic and fat tissue accumulation in the heart. The cellular origin...
5.
Molenaar B, Timmer L, Droog M, Perini I, Versteeg D, Kooijman L, et al.
Commun Biol
. 2021 Jan;
4(1):146.
PMID: 33514846
The efficiency of the repair process following ischemic cardiac injury is a crucial determinant for the progression into heart failure and is controlled by both intra- and intercellular signaling within...
6.
Gladka M, Kohela A, Molenaar B, Versteeg D, Kooijman L, Monshouwer-Kloots J, et al.
Nat Commun
. 2021 Jan;
12(1):84.
PMID: 33398012
The disruption in blood supply due to myocardial infarction is a critical determinant for infarct size and subsequent deterioration in function. The identification of factors that enhance cardiac repair by...
7.
Molenaar B, Van Rooij E
Circ Res
. 2018 Oct;
123(9):1033-1035.
PMID: 30355162
No abstract available.
8.
Gladka M, Molenaar B, de Ruiter H, van der Elst S, Tsui H, Versteeg D, et al.
Circulation
. 2018 Feb;
138(2):166-180.
PMID: 29386203
Background: Genome-wide transcriptome analysis has greatly advanced our understanding of the regulatory networks underlying basic cardiac biology and mechanisms driving disease. However, so far, the resolution of studying gene expression...
9.
Johansen A, Molenaar B, Versteeg D, Leitoguinho A, Demkes C, Spanjaard B, et al.
Circ Res
. 2017 Aug;
121(10):1168-1181.
PMID: 28851809
Rationale: CRISPR/Cas9 (clustered regularly interspaced palindromic repeats/CRISPR-associated protein 9)-based DNA editing has rapidly evolved as an attractive tool to modify the genome. Although CRISPR/Cas9 has been extensively used to manipulate...
10.
Lacraz G, Junker J, Gladka M, Molenaar B, Scholman K, Vigil-Garcia M, et al.
Circulation
. 2017 Jul;
136(15):1396-1409.
PMID: 28724751
Background: Cardiac ischemic injury induces a pathological remodeling response, which can ultimately lead to heart failure. Detailed mechanistic insights into molecular signaling pathways relevant for different aspects of cardiac remodeling...