Bartlomiej Szulczyk
Overview
Explore the profile of Bartlomiej Szulczyk including associated specialties, affiliations and a list of published articles.
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29
Citations
134
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Recent Articles
1.
Jakubiec M, Abram M, Zagaja M, Socala K, Panic V, Latacz G, et al.
ACS Chem Neurosci
. 2024 Aug;
15(17):3228-3256.
PMID: 39166702
We developed a focused series of original phenyl-glycinamide derivatives which showed potent activity across mouse seizure models, namely, maximal electroshock (MES) and 6 Hz (using both 32 and 44 mA...
2.
Jakubiec M, Abram M, Zagaja M, Andres-Mach M, Szala-Rycaj J, Latacz G, et al.
ACS Chem Neurosci
. 2024 May;
15(11):2198-2222.
PMID: 38741575
In the present study, a series of original alaninamide derivatives have been designed applying a combinatorial chemistry approach, synthesized, and characterized in the and assays. The obtained molecules showed potent...
3.
Witkowski G, Szulczyk B, Nurowska E, Jurek M, Pasierski M, Lipiec A, et al.
Int J Mol Sci
. 2024 Feb;
25(3).
PMID: 38339022
Mutations of the gene, which encodes the voltage-dependent Na channel's α subunit, are associated with diverse epileptic syndromes ranging in severity, even intra-family, from febrile seizures to epileptic encephalopathy. The...
4.
Pasierski M, Kolba W, Szulczyk B
Pharmacol Rep
. 2023 Feb;
75(2):331-341.
PMID: 36800106
Background: Guanfacine (an alpha-2A receptor agonist) is a commonly used drug with recognized efficacy in the treatment of attention deficit hyperactivity disorder (ADHD). This study aimed to assess the effects...
5.
Abram M, Jakubiec M, Reeb K, Cheng M, Gedschold R, Rapacz A, et al.
J Med Chem
. 2022 Aug;
65(17):11703-11725.
PMID: 35984707
[] showed broad-spectrum antiseizure activity across mouse seizure models: maximal electroshock (MES), 6 Hz (32/44 mA), acute pentylenetetrazol (PTZ), and PTZ-kindling. A remarkable separation between antiseizure activity and CNS-related adverse...
6.
Jakubiec M, Abram M, Zagaja M, Andres-Mach M, Szewczyk A, Latacz G, et al.
Cells
. 2022 Jun;
11(12).
PMID: 35740990
In the present study, a focused combinatorial chemistry approach was applied to merge structural fragments of well-known TRPV1 antagonists with a potent anticonvulsant lead compound, , that was previously discovered...
7.
Pasierski M, Szulczyk B
Molecules
. 2022 Apr;
27(8).
PMID: 35458680
Capsaicin is a natural compound found in chili peppers and is used in the diet of many countries. The important mechanism of action of capsaicin is its influence on TRPV1...
8.
Szulczyk B, Spyrka A
Brain Res
. 2022 Mar;
1783:147847.
PMID: 35227652
Menthol is a natural compound that evokes cold sensations by activating TRPM8 channels in peripheral sensory receptors. Little is known about the effects of this compound on brain neurons. It...
9.
Abram M, Jakubiec M, Rapacz A, Mogilski S, Latacz G, Szulczyk B, et al.
Int J Mol Sci
. 2021 Dec;
22(23).
PMID: 34884898
We report herein a series of water-soluble analogues of previously described anticonvulsants and their detailed in vivo and in vitro characterization. The majority of these compounds demonstrated broad-spectrum anticonvulsant properties...
10.
Prefrontal cortex pyramidal neurons express functional Nav1.8 tetrodotoxin-resistant sodium currents
Szulczyk B, Pasierski M, Gawlak M
Clin Exp Pharmacol Physiol
. 2021 Nov;
49(3):350-359.
PMID: 34750860
It has been repeatedly proved that Nav1.8 tetrodotoxin (TTX)-resistant sodium currents are expressed in peripheral sensory neurons where they play important role in nociception. There are very few publications that...