Rafal M Kaminski
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Explore the profile of Rafal M Kaminski including associated specialties, affiliations and a list of published articles.
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76
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1666
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Recent Articles
1.
Kaminski K, Socala K, Abram M, Jakubiec M, Reeb K, Temmermand R, et al.
Ann Neurol
. 2024 Nov;
97(2):344-357.
PMID: 39512205
Objective: Excitotoxicity is a common hallmark of epilepsy and other neurological diseases associated with elevated extracellular glutamate levels. Thus, here, we studied the protective effects of (R)-AS-1, a positive allosteric...
2.
Jakubiec M, Abram M, Zagaja M, Socala K, Panic V, Latacz G, et al.
ACS Chem Neurosci
. 2024 Aug;
15(17):3228-3256.
PMID: 39166702
We developed a focused series of original phenyl-glycinamide derivatives which showed potent activity across mouse seizure models, namely, maximal electroshock (MES) and 6 Hz (using both 32 and 44 mA...
3.
Klein P, Kaminski R, Koepp M, Loscher W
Nat Rev Drug Discov
. 2024 Jul;
23(9):682-708.
PMID: 39039153
Epilepsy is a common brain disorder, characterized by spontaneous recurrent seizures, with associated neuropsychiatric and cognitive comorbidities and increased mortality. Although people at risk can often be identified, interventions to...
4.
Socala K, Jakubiec M, Abram M, Mlost J, Starowicz K, Kaminski R, et al.
Prog Neurobiol
. 2024 Jun;
240:102634.
PMID: 38834133
Identification of transient receptor potential cation channel, subfamily V member 1 (TRPV1), also known as capsaicin receptor, in 1997 was a milestone achievement in the research on temperature sensation and...
5.
Jakubiec M, Abram M, Zagaja M, Andres-Mach M, Szala-Rycaj J, Latacz G, et al.
ACS Chem Neurosci
. 2024 May;
15(11):2198-2222.
PMID: 38741575
In the present study, a series of original alaninamide derivatives have been designed applying a combinatorial chemistry approach, synthesized, and characterized in the and assays. The obtained molecules showed potent...
6.
Mahmud M, Wade C, Jawad S, Hadi Z, Otoul C, Kaminski R, et al.
Front Neuroimaging
. 2023 Aug;
2:1142463.
PMID: 37554649
Objective: Translocator protein (TSPO) targeting positron emission tomography (PET) imaging radioligands have potential utility in epilepsy to assess the efficacy of novel therapeutics for targeting neuroinflammation. However, previous studies in...
7.
Abram M, Jakubiec M, Reeb K, Cheng M, Gedschold R, Rapacz A, et al.
J Med Chem
. 2022 Aug;
65(17):11703-11725.
PMID: 35984707
[] showed broad-spectrum antiseizure activity across mouse seizure models: maximal electroshock (MES), 6 Hz (32/44 mA), acute pentylenetetrazol (PTZ), and PTZ-kindling. A remarkable separation between antiseizure activity and CNS-related adverse...
8.
Jakubiec M, Abram M, Zagaja M, Andres-Mach M, Szewczyk A, Latacz G, et al.
Cells
. 2022 Jun;
11(12).
PMID: 35740990
In the present study, a focused combinatorial chemistry approach was applied to merge structural fragments of well-known TRPV1 antagonists with a potent anticonvulsant lead compound, , that was previously discovered...
9.
Zhang Y, Heylen L, Partoens M, Mills J, Kaminski R, Godard P, et al.
Front Mol Neurosci
. 2022 Jun;
15:881933.
PMID: 35686059
Synaptic vesicle glycoprotein 2A (SV2A) regulates action potential-dependent neurotransmitter release and is commonly known as the primary binding site of an approved anti-epileptic drug, levetiracetam. Although several rodent knockout models...
10.
Sklepkiewicz P, Dymek B, Mlacki M, Koralewski R, Mazur M, Nejman-Gryz P, et al.
Eur J Pharmacol
. 2022 Feb;
919:174792.
PMID: 35122869
Idiopathic pulmonary fibrosis (IPF) is a progressive and eventually fatal lung disease with a complex etiology. Approved drugs, nintedanib and pirfenidone, modify disease progression, but IPF remains incurable and there...