Szczepan Mogilski
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Explore the profile of Szczepan Mogilski including associated specialties, affiliations and a list of published articles.
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Citations
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Recent Articles
1.
Karcz T, Szczepanska K, Mogilski S, Moroz A, Olejarz-Maciej A, Humphrys L, et al.
ACS Chem Neurosci
. 2024 Dec;
15(24):4441-4457.
PMID: 39652796
In this study, we selected 12 guanidine derivatives from the previously described ligand library and determined their affinity at histamine H and H receptors (HR and HR, respectively). Moreover, we...
2.
Jakubiec M, Abram M, Zagaja M, Socala K, Panic V, Latacz G, et al.
ACS Chem Neurosci
. 2024 Aug;
15(17):3228-3256.
PMID: 39166702
We developed a focused series of original phenyl-glycinamide derivatives which showed potent activity across mouse seizure models, namely, maximal electroshock (MES) and 6 Hz (using both 32 and 44 mA...
3.
Jakubiec M, Abram M, Zagaja M, Andres-Mach M, Szala-Rycaj J, Latacz G, et al.
ACS Chem Neurosci
. 2024 May;
15(11):2198-2222.
PMID: 38741575
In the present study, a series of original alaninamide derivatives have been designed applying a combinatorial chemistry approach, synthesized, and characterized in the and assays. The obtained molecules showed potent...
4.
Kubacka M, Nowak B, Zadrozna M, Szafarz M, Latacz G, Marona H, et al.
Metabolites
. 2023 Nov;
13(11).
PMID: 37999226
Excessive fructose consumption may lead to metabolic syndrome, metabolic dysfunction-associated fatty liver disease (MAFLD) and hypertension. α1-adrenoceptors antagonists are antihypertensive agents that exert mild beneficial effects on the metabolic profile...
5.
Mogilski S, Kubacka M, Swierczek A, Wyska E, Szczepanska K, Sapa J, et al.
Pharmaceuticals (Basel)
. 2023 Oct;
16(10).
PMID: 37895952
Itch and pain are closely related but distinct sensations that share largely overlapping mediators and receptors. We hypothesized that the novel, multi-target compound E153 has the potential to attenuate pain...
6.
Kubacka M, Mogilski S, Bednarski M, Pociecha K, Swierczek A, Nicosia N, et al.
Int J Mol Sci
. 2023 Sep;
24(17).
PMID: 37686188
The platelet aggregation inhibitory activity of selected xanthine-based adenosine A and A receptor antagonists was investigated, and attempts were made to explain the observed effects. The selective A receptor antagonist...
7.
Szczepanska K, Karcz T, Dichiara M, Mogilski S, Kalinowska-Tluscik J, Pilarski B, et al.
J Med Chem
. 2023 Jul;
66(14):9658-9683.
PMID: 37418295
In search of new dual-acting histamine H/sigma-1 receptor ligands, we designed a series of compounds structurally based on highly active ligands previously studied and described by our team. However, we...
8.
Olejarz-Maciej A, Mogilski S, Karcz T, Werner T, Kaminska K, Kupczyk J, et al.
Molecules
. 2023 May;
28(10).
PMID: 37241939
Pain is a very unpleasant experience that makes life extremely uncomfortable. The histamine H receptor (HR) is a promising target for the treatment of inflammatory and immune diseases, as well...
9.
Godyn J, Zareba P, Stary D, Kaleta M, Kuder K, Latacz G, et al.
Molecules
. 2023 Jan;
28(1).
PMID: 36615435
The multitarget-directed ligands demonstrating affinity to histamine H receptor and additional cholinesterase inhibitory potency represent a promising strategy for research into the effective treatment of Alzheimer's disease. In this study,...
10.
Abram M, Jakubiec M, Reeb K, Cheng M, Gedschold R, Rapacz A, et al.
J Med Chem
. 2022 Aug;
65(17):11703-11725.
PMID: 35984707
[] showed broad-spectrum antiseizure activity across mouse seizure models: maximal electroshock (MES), 6 Hz (32/44 mA), acute pentylenetetrazol (PTZ), and PTZ-kindling. A remarkable separation between antiseizure activity and CNS-related adverse...