Bart L van den Eshof
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Explore the profile of Bart L van den Eshof including associated specialties, affiliations and a list of published articles.
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9
Citations
118
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Recent Articles
1.
Groten S, van den Eshof B, van Alphen F, Meijer A, van den Biggelaar M, Hoogendijk A
J Thromb Haemost
. 2024 Oct;
23(2):717-730.
PMID: 39442624
Background: The vascular endothelial cell (EC) monolayer plays a crucial part in maintaining hemostasis. An extensive array of G protein-coupled receptors allows ECs to dynamically act on key hemostatic stimuli...
2.
Groten S, Smit E, Janssen E, van den Eshof B, van Alphen F, van der Zwaan C, et al.
Commun Biol
. 2023 May;
6(1):525.
PMID: 37188730
Vascular endothelial cells (ECs) form a dynamic interface between blood and tissue and play a crucial role in the progression of vascular inflammation. Here, we aim to dissect the system-wide...
3.
van den Eshof B, Medfai L, Nolfi E, Wawrzyniuk M, Sijts A
Cells
. 2021 Dec;
10(12).
PMID: 34943869
Proteasomes are responsible for intracellular proteolysis and play an important role in cellular protein homeostasis. Cells of the immune system assemble a specialized form of proteasomes, known as immunoproteasomes, in...
4.
Schmidlin T, Debets D, van Gelder C, Stecker K, Rontogianni S, van den Eshof B, et al.
Cell Syst
. 2019 Sep;
9(4):366-374.e5.
PMID: 31521607
Aberrant kinase activity has been linked to a variety of disorders; however, methods to probe kinase activation states in cells have been lacking. Until now, kinase activity has mainly been...
5.
Beguin E, van den Eshof B, Hoogendijk A, Nota B, Mertens K, Meijer A, et al.
J Proteomics
. 2018 Aug;
192:89-101.
PMID: 30153514
The vascular endothelium provides a unique interaction plane for plasma proteins and leukocytes in inflammation. The pro-inflammatory cytokines Tumor Necrosis Factor α (TNFα) and interleukin 1β (IL-1β) have a profound...
6.
Schillemans M, Karampini E, van den Eshof B, Gangaev A, Hofman M, van Breevoort D, et al.
Arterioscler Thromb Vasc Biol
. 2018 Jun;
38(7):1549-1561.
PMID: 29880488
Objective: Endothelial cells store VWF (von Willebrand factor) in rod-shaped secretory organelles, called Weibel-Palade bodies (WPBs). WPB exocytosis is coordinated by a complex network of Rab GTPases, Rab effectors, and...
7.
Rijkers M, van den Eshof B, van der Meer P, van Alphen F, de Korte D, Leebeek F, et al.
Sci Rep
. 2017 Sep;
7(1):11045.
PMID: 28887518
Shelf life of platelet concentrates is limited to 5-7 days due to loss of platelet function during storage, commonly referred to as the platelet storage lesion (PSL). To get more...
8.
van den Eshof B, Hoogendijk A, Simpson P, van Alphen F, Zanivan S, Mertens K, et al.
Arterioscler Thromb Vasc Biol
. 2017 Aug;
37(10):1891-1902.
PMID: 28818855
Objective: Thrombin is the key serine protease of the coagulation cascade and mediates cellular responses by activation of PARs (protease-activated receptors). The predominant thrombin receptor is PAR1, and in endothelial...
9.
van den Biggelaar M, Hernandez-Fernaud J, van den Eshof B, Neilson L, Meijer A, Mertens K, et al.
Blood
. 2014 Feb;
123(12):e22-36.
PMID: 24501219
Thrombin is the key serine protease of the coagulation cascade and a potent trigger of protease-activated receptor 1 (PAR1)-mediated platelet aggregation. In recent years, PAR1 has become an appealing target...