Barry M Twenter
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Explore the profile of Barry M Twenter including associated specialties, affiliations and a list of published articles.
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8
Citations
125
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Recent Articles
1.
Wangtrakuldee P, Adeniji A, Zang T, Duan L, Khatri B, Twenter B, et al.
J Steroid Biochem Mol Biol
. 2019 Jan;
192:105283.
PMID: 30641225
Drugs used for the treatment of castration resistant prostate cancer (CRPC) include Abiraterone acetate (Zytiga®) and Enzalutamide (XTANDI®). However, these drugs provide clinical benefit in metastatic disease for only a...
2.
Leung J, Bedermann A, Njardarson J, Spiegel D, Murphy G, Hama N, et al.
Angew Chem Int Ed Engl
. 2017 Dec;
57(7):1991-1994.
PMID: 29286556
Described herein is a synthetic strategy for the total synthesis of (±)-phomoidride D. This highly efficient and stereoselective approach provides rapid assembly of the carbocyclic core by way of a...
3.
Winkler J, Twenter B, Gendrineau T
Heterocycles
. 2014 Jan;
84(2).
PMID: 24403722
A new method for the "ligation" of two aromatic rings has been achieved via synthesis of functionalized phenazines by double Buchwald-Hartwig cyclization of a variety of substituted bromoanilines.
4.
Murphy G, Shirahata T, Hama N, Bedermann A, Dong P, McMahon T, et al.
J Org Chem
. 2012 Dec;
78(2):477-89.
PMID: 23245580
An efficient and highly stereoselective approach toward the phomoidride family of natural products is described. The carbocyclic core structure was assembled using a tandem phenolic oxidation/Diels-Alder cycloaddition and a tandem...
5.
Murphy G, Hama N, Bedermann A, Dong P, Schneider C, McMahon T, et al.
Org Lett
. 2012 Aug;
14(17):4544-7.
PMID: 22917221
The carbocyclic core of the phomoidrides has been synthesized efficiently and in high yield. Key steps include a phenolic oxidation/intramolecular Diels-Alder sequence, tandem radical cyclization, and a late-stage Wharton fragmentation...
6.
Chen M, Adeniji A, Twenter B, Winkler J, Christianson D, Penning T
Bioorg Med Chem Lett
. 2012 Apr;
22(10):3492-7.
PMID: 22507964
Castrate resistant prostate cancer (CRPC) is associated with increased androgen receptor (AR) signaling often brought about by elevated intratumoral androgen biosynthesis and AR amplification. Inhibition of androgen biosynthesis and/or AR...
7.
Adeniji A, Twenter B, Byrns M, Jin Y, Chen M, Winkler J, et al.
J Med Chem
. 2012 Jan;
55(5):2311-23.
PMID: 22263837
Aldo-keto reductase 1C3 (AKR1C3; type 5 17β-hydroxysteroid dehydrogenase) is overexpressed in castration resistant prostate cancer (CRPC) and is implicated in the intratumoral biosynthesis of testosterone and 5α-dihydrotestosterone. Selective AKR1C3 inhibitors...
8.
Adeniji A, Twenter B, Byrns M, Jin Y, Winkler J, Penning T
Bioorg Med Chem Lett
. 2011 Feb;
21(5):1464-8.
PMID: 21277203
Aldo-keto reductase 1C3 (AKR1C3) also known as type 5 17β-hydroxysteroid dehydrogenase has been implicated as one of the key enzymes driving the elevated intratumoral androgen levels observed in castrate resistant...