Barbara Ludeke
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Explore the profile of Barbara Ludeke including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
220
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Recent Articles
1.
Hu S, Kim H, Yang P, Yu Z, Ludeke B, Mobilia S, et al.
Cell
. 2025 Jan;
188(3):688-703.e18.
PMID: 39837328
Nipah virus (NiV) is a bat-borne, zoonotic RNA virus that is highly pathogenic in humans. The NiV polymerase, which mediates viral genome replication and mRNA transcription, is a promising drug...
2.
Xie J, Ouizougun-Oubari M, Wang L, Zhai G, Wu D, Lin Z, et al.
Nat Commun
. 2024 Apr;
15(1):3163.
PMID: 38605025
The transcription and replication processes of non-segmented, negative-strand RNA viruses (nsNSVs) are catalyzed by a multi-functional polymerase complex composed of the large protein (L) and a cofactor protein, such as...
3.
Shareef A, Ludeke B, Jordan P, Deval J, Fearns R
PLoS Pathog
. 2021 Dec;
17(12):e1010151.
PMID: 34914795
It is generally thought that the promoters of non-segmented, negative strand RNA viruses (nsNSVs) direct the polymerase to initiate RNA synthesis exclusively opposite the 3´ terminal nucleotide of the genome...
4.
Blanchard E, Braun M, Lifland A, Ludeke B, Noton S, Vanover D, et al.
PLoS Pathog
. 2020 Oct;
16(10):e1008987.
PMID: 33031461
The ribonucleocapsid complex of respiratory syncytial virus (RSV) is responsible for both viral mRNA transcription and viral replication during infection, though little is known about how this dual function is...
5.
Ludeke B, Fearns R
Virology
. 2019 Nov;
540:66-74.
PMID: 31739186
Respiratory syncytial virus (RSV) is significant for public health, capable of causing respiratory tract disease in infants, the elderly and the immunocompromised. The RSV polymerase is an attractive target for...
6.
Pan J, Qian X, Lattmann S, El Sahili A, Yeo T, Jia H, et al.
Nature
. 2019 Nov;
577(7789):275-279.
PMID: 31698413
Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) cause severe respiratory diseases in infants and elderly adults. No vaccine or effective antiviral therapy currently exists to control RSV or HMPV...
7.
Cox R, Toots M, Yoon J, Sourimant J, Ludeke B, Fearns R, et al.
J Biol Chem
. 2018 Sep;
293(43):16761-16777.
PMID: 30206124
Respiratory syncytial virus (RSV) represents a significant health threat to infants and to elderly or immunocompromised individuals. There are currently no vaccines available to prevent RSV infections, and disease management...
8.
Yoon J, Toots M, Lee S, Lee M, Ludeke B, Luczo J, et al.
Antimicrob Agents Chemother
. 2018 Jun;
62(8).
PMID: 29891600
Morbidity and mortality resulting from influenza-like disease are a threat, especially for older adults. To improve case management, next-generation broad-spectrum antiviral therapeutics that are efficacious against major drivers of influenza-like...
9.
Duvall J, VerPlank L, Ludeke B, McLeod S, Lee 4th M, Vishwanathan K, et al.
Antiviral Res
. 2016 Apr;
131:19-25.
PMID: 27059228
Respiratory syncytial virus (RSV) infections affect millions of children and adults every year. Despite the significant disease burden, there are currently no safe and effective vaccines or therapeutics. We employed...