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Barbara Kapron

Explore the profile of Barbara Kapron including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 31
Citations 205
Followers 0
Related Specialties
Biochemistry
Chemistry
Biology
Top 10 Co-Authors
Tomasz Plech
Agata Paneth
Boguslaw Buszewski
Anna Petruczynik
Anna Makuch-Kocka
Malgorzata Szultka-Mlynska
Gabriel Nowak
Nazar Trotsko
Monika Wujec
Urszula Kosikowska
Published In
Molecules
J Enzyme Inhib Med Chem
Int J Mol Sci
Eur J Med Chem
Pharmaceutics
Affiliations
Soon will be listed here.
Recent Articles
1.
The new thiazolidine-2,4-dione-based hybrids with promising antimycobacterial activity: design, synthesis, biological evaluation, and drug interaction analysis
Trotsko N, Glogowska A, Kapron B, Koziel K, Augustynowicz-Kopec E, Paneth A
J Enzyme Inhib Med Chem . 2025 Jan; 40(1):2442703. PMID: 39749402
The ever-increasing drug-resistant tuberculosis (TB) has invigorated the focus on the discovery and development of novel therapeutic agents and treatment options. Thiazolidinone-based compounds have shown good antitubercular properties . Here,...
2.
In Vitro and In Silico of Cholinesterases Inhibition and In Vitro and In Vivo Anti-Melanoma Activity Investigations of Extracts Obtained from Selected Species
Tuzimski T, Petruczynik A, Kapron B, Plech T, Makuch-Kocka A, Janiszewska D, et al.
Molecules . 2024 Mar; 29(5). PMID: 38474561
species have a long history of use in traditional Chinese medicine, Ayurvedic medicine, and Western herbal medicine. The aim of this study was the quantification of the main isoquinoline alkaloids...
3.
Combined In Silico and In Vitro Analyses to Assess the Anticancer Potential of Thiazolidinedione-Thiosemicarbazone Hybrid Molecules
Paneth A, Kapron B, Plech T, Paduch R, Trotsko N, Paneth P
Int J Mol Sci . 2023 Dec; 24(24). PMID: 38139350
The number of people affected by cancer and antibiotic-resistant bacterial infections has increased, such that both diseases are already seen as current and future leading causes of death globally. To...
4.
Effect of Linker Elongation on the VGSC Affinity and Anticonvulsant Activity among 4-Alkyl-5-aryl-1,2,4-triazole-3-thione Derivatives
Paruch K, Kapron B, Luszczki J, Paneth A, Plech T
Molecules . 2023 Jul; 28(13). PMID: 37446948
The main aim of the current project was to investigate the effect of the linker size in 4-alkyl-5-aryl-1,2,4-triazole-3-thione derivatives, known as a group of antiepileptic drug candidates, on their affinity...
5.
Determination of Some Isoquinoline Alkaloids in Extracts Obtained from Selected Plants of the Ranunculaceae, Papaveraceae and Fumarioideae Families by Liquid Chromatography and In Vitro and In Vivo Investigations of Their Cytotoxic Activity
Misiurek J, Plech T, Kapron B, Makuch-Kocka A, Szultka-Mlynska M, Buszewski B, et al.
Molecules . 2023 Apr; 28(8). PMID: 37110737
Alkaloids are heterocyclic bases with widespread occurrence in nature. Plants are rich and easily accessible sources of them. Most isoquinoline alkaloids have cytotoxic activity for different types of cancer, including...
6.
Determination of Selected Isoquinoline Alkaloids from , and Extracts by Liquid Chromatography and Their In Vitro and In Vivo Cytotoxic Activity against Human Cancer Cells
Tuzimski T, Petruczynik A, Plech T, Kapron B, Makuch-Kocka A, Szultka-Mlynska M, et al.
Int J Mol Sci . 2023 Apr; 24(7). PMID: 37047332
The search for new substances with cytotoxic activity against various cancer cells, especially cells that are very resistant to currently used chemotherapeutic agents, such as melanoma cells, is a very...
7.
Thiosemicarbazide Derivatives Targeting Human TopoIIα and IDO-1 as Small-Molecule Drug Candidates for Breast Cancer Treatment
Kapron B, Czarnomysy R, Radomska D, Bielawski K, Plech T
Int J Mol Sci . 2023 Mar; 24(6). PMID: 36982886
In 2020, breast cancer became the most frequently diagnosed type of cancer, with nearly 2.3 million new cases diagnosed. However, with early diagnosis and proper treatment, breast cancer has a...
8.
TZD-Based Hybrid Molecules Act as Dual Anti- and Anti- Agents
Dzitko K, Kapron B, Paneth A, Bekier A, Plech T, Paneth P, et al.
Int J Mol Sci . 2023 Feb; 24(3). PMID: 36768392
Two distinct intracellular pathogens, namely and cause major public health problems worldwide. In addition, serious and challenging health problems of co-infections of with have been recorded, especially in developing countries....
9.
Identification of the first-in-class dual inhibitors of human DNA topoisomerase IIα and indoleamine-2,3-dioxygenase 1 (IDO 1) with strong anticancer properties
Kapron B, Plazinska A, Plazinski W, Plech T
J Enzyme Inhib Med Chem . 2022 Nov; 38(1):192-202. PMID: 36345785
Molecular docking of a large set of thiosemicarbazide-based ligands resulted in obtaining compounds that inhibited both human DNA topoisomerase IIα and indoleamine-2,3-dioxygenase-1 (IDO1). To the best of our knowledge, these...
10.
Inhibition of by 1,2,4-triazole-based compounds: marked improvement in selectivity relative to the standard therapy pyrimethamine and sulfadiazine
Weglinska L, Bekier A, Trotsko N, Kapron B, Plech T, Dzitko K, et al.
J Enzyme Inhib Med Chem . 2022 Sep; 37(1):2621-2634. PMID: 36165032
A safer treatment for toxoplasmosis would be achieved by improving the selectivity profile of novel chemotherapeutics compared to the standard therapy pyrimethamine (PYR) and sulfadiazine (SDZ). We previously reported on...