Barbara H Iglewski
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Explore the profile of Barbara H Iglewski including associated specialties, affiliations and a list of published articles.
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23
Citations
1893
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Recent Articles
1.
Filiatrault M, Tombline G, Wagner V, Van Alst N, Rumbaugh K, Sokol P, et al.
PLoS One
. 2013 Feb;
8(2):e55594.
PMID: 23409004
Pseudomonas aeruginosa (Pae) is a clinically important opportunistic pathogen. Herein, we demonstrate that the PA1006 protein is critical for all nitrate reductase activities, growth as a biofilm in a continuous...
2.
Tombline G, Schwingel J, Lapek Jr J, Friedman A, Darrah T, Maguire M, et al.
PLoS One
. 2013 Feb;
8(2):e55593.
PMID: 23409003
A companion manuscript revealed that deletion of the Pseudomonas aeruginosa (Pae) PA1006 gene caused pleiotropic defects in metabolism including a loss of all nitrate reductase activities, biofilm maturation, and virulence....
3.
Van Alst N, Sherrill L, Iglewski B, Haidaris C
Can J Microbiol
. 2009 Nov;
55(10):1133-44.
PMID: 19935885
Nitrate serves as a terminal electron acceptor under anaerobic conditions in Pseudomonas aeruginosa. Reduction of nitrate to nitrite generates a transmembrane proton motive force allowing ATP synthesis and anaerobic growth....
4.
Van Alst N, Wellington M, Clark V, Haidaris C, Iglewski B
Infect Immun
. 2009 Aug;
77(10):4446-54.
PMID: 19651860
The nitrate dissimilation pathway is important for anaerobic growth in Pseudomonas aeruginosa. In addition, this pathway contributes to P. aeruginosa virulence by using the nematode Caenorhabditis elegans as a model...
5.
Wagner V, Iglewski B
Clin Rev Allergy Immunol
. 2008 May;
35(3):124-34.
PMID: 18509765
Pseudomonas aeruginosa is an opportunistic pathogen of immunocompromised hosts. In cystic fibrosis (CF), P. aeruginosa causes acute and chronic lung infections that result in significant morbidity and mortality. P. aeruginosa...
6.
Morici L, Carterson A, Wagner V, Frisk A, Schurr J, Bentrup K, et al.
J Bacteriol
. 2007 Sep;
189(21):7752-64.
PMID: 17766417
AlgR controls numerous virulence factors in Pseudomonas aeruginosa, including alginate, hydrogen cyanide production, and type IV pilus-mediated twitching motility. In this study, the role of AlgR in biofilms was examined...
7.
Van Alst N, Picardo K, Iglewski B, Haidaris C
Infect Immun
. 2007 May;
75(8):3780-90.
PMID: 17526746
Infection by the bacterial opportunist Pseudomonas aeruginosa frequently assumes the form of a biofilm, requiring motility for biofilm formation and dispersal and an ability to grow in nutrient- and oxygen-limited...
8.
Li L, Malone J, Iglewski B
J Bacteriol
. 2007 Apr;
189(12):4367-74.
PMID: 17449616
Bacteria communicate with each other to regulate cell density-dependent gene expression via a quorum-sensing (QS) cascade. In Pseudomonas aeruginosa, two known QS systems, las and rhl, control the expression of...
9.
Wagner V, Li L, Isabella V, Iglewski B
Anal Bioanal Chem
. 2006 Dec;
387(2):469-79.
PMID: 17139483
Quorum-sensing in Pseudomonas aeruginosa is known to regulate several aspects of pathogenesis, including virulence factor production, biofilm development, and antimicrobial resistance. Recent high-throughput analysis has revealed the existence of several...
10.
Matsui H, Wagner V, Hill D, Schwab U, Rogers T, Button B, et al.
Proc Natl Acad Sci U S A
. 2006 Nov;
103(48):18131-6.
PMID: 17116883
A vexing problem in cystic fibrosis (CF) pathogenesis has been to explain the high prevalence of Pseudomonas aeruginosa biofilms in CF airways. We speculated that airway surface liquid (ASL) hyperabsorption...