Barbara Dema
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Explore the profile of Barbara Dema including associated specialties, affiliations and a list of published articles.
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25
Citations
1232
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Recent Articles
11.
Pellefigues C, Dema B, Lamri Y, Saidoune F, Chavarot N, Loheac C, et al.
Nat Commun
. 2018 Feb;
9(1):725.
PMID: 29463843
In systemic lupus erythematosus (SLE), autoantibody production can lead to kidney damage and failure, known as lupus nephritis. Basophils amplify the synthesis of autoantibodies by accumulating in secondary lymphoid organs....
12.
Dema B, Lamri Y, Pellefigues C, Pacreau E, Saidoune F, Bidault C, et al.
Sci Rep
. 2017 Aug;
7(1):7969.
PMID: 28801578
Lupus nephritis (LN), one of the most severe outcomes of systemic lupus erythematosus (SLE), is initiated by glomerular deposition of immune-complexes leading to an inflammatory response and kidney failure. Autoantibodies...
13.
Villarino A, Laurence A, Robinson G, Bonelli M, Dema B, Afzali B, et al.
Elife
. 2016 Mar;
5.
PMID: 26999798
The transcription factor STAT5 is fundamental to the mammalian immune system. However, the relationship between its two paralogs, STAT5A and STAT5B, and the extent to which they are functionally distinct,...
14.
Dema B, Charles N, Pellefigues C, Ricks T, Suzuki R, Jiang C, et al.
J Exp Med
. 2014 Oct;
211(11):2159-68.
PMID: 25267791
The (patho)physiological role of IgE in nonallergic inflammatory diseases is not well understood. Here, we explored the effect of IgE deficiency on the inflammatory response in FcγRIIB-deficient mice as well...
15.
Dema B, Suzuki R, Rivera J
Int Arch Allergy Immunol
. 2014 Sep;
164(4):271-9.
PMID: 25227903
Immunoglobulin E (IgE) and its high-affinity receptor (FcεRI) are well-known participants in the allergic response. The interaction of allergens with FcεRI-bound IgE antibodies is an essential step in mast cell/basophil...
16.
Dema B, Charles N
Discov Med
. 2014 Jun;
17(95):247-55.
PMID: 24882716
Systemic lupus erythematosus (SLE) is a complex autoimmune disease associated with hormonal, environmental, and genetic factors and linked to the tolerance breakdown of B and T cells to self-antigens. SLE...
17.
Dema B, Pellefigues C, Hasni S, Gault N, Jiang C, Ricks T, et al.
PLoS One
. 2014 Mar;
9(2):e90424.
PMID: 24587356
The presence of autoantibodies in systemic lupus erythematosus, particularly those of the IgG subclass, have long been associated with disease onset and activity. Here we explored the prevalence of autoreactive...
18.
Roychoudhuri R, Hirahara K, Mousavi K, Clever D, Klebanoff C, Bonelli M, et al.
Nature
. 2013 Jun;
498(7455):506-10.
PMID: 23728300
Through their functional diversification, distinct lineages of CD4(+) T cells can act to either drive or constrain immune-mediated pathology. Transcription factors are critical in the generation of cellular diversity, and...
19.
Medrano L, Dema B, Lopez-Larios A, Maluenda C, Bodas A, Lopez-Palacios N, et al.
PLoS One
. 2012 Nov;
7(10):e48403.
PMID: 23119005
Celiac disease (CD) is a chronic inflammatory disorder triggered after gluten ingestion in genetically susceptible individuals. The major genetic determinants are HLA-DQA1*05 and HLA-DQB1*02, which encode the DQ2 heterodimer. These...
20.
Medrano L, Garcia-Magarinos M, Dema B, Espino L, Maluenda C, Polanco I, et al.
PLoS One
. 2012 Feb;
7(2):e31244.
PMID: 22359581
Th17 cells are known to be involved in several autoimmune or inflammatory diseases. In celiac disease (CD), recent studies suggest an implication of those cells in disease pathogenesis. We aimed...