Baojun Chang
Overview
Explore the profile of Baojun Chang including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
663
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0
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Recent Articles
1.
Shen Y, Goncharov D, Pena A, Baust J, Chavez Barragan A, Ray A, et al.
Sci Signal
. 2022 Dec;
15(763):eabn2743.
PMID: 36473049
Increased proliferation and survival of cells in small pulmonary arteries (PAs) drive pulmonary arterial hypertension (PAH). Because cell growth mediated by the mTOR-containing mTORC1 complex is inhibited by tuberous sclerosis...
2.
Jiang L, Goncharov D, Shen Y, Lin D, Chang B, Pena A, et al.
Front Med (Lausanne)
. 2022 Jul;
9:886868.
PMID: 35836951
Hyper-proliferation of pulmonary arterial vascular smooth muscle cells (PAVSMC) is an important pathological component of pulmonary vascular remodeling in pulmonary arterial hypertension (PAH). Lipogenesis is linked to numerous proliferative diseases,...
3.
Sharifi-Sanjani M, Berman M, Goncharov D, Alhamaydeh M, Avolio T, Baust J, et al.
Int J Mol Sci
. 2021 Jul;
22(11).
PMID: 34200497
Left ventricular (LV) heart failure (HF) is a significant and increasing cause of death worldwide. HF is characterized by myocardial remodeling and excessive fibrosis. Transcriptional co-activator Yes-associated protein (Yap), the...
4.
Wu H, Rahman H, Dong Y, Liu X, Lee Y, Wen A, et al.
J Clin Invest
. 2018 Aug;
128(9):4025-4043.
PMID: 30102256
Impaired lymphangiogenesis is a complication of chronic complex diseases, including diabetes. VEGF-C/VEGFR3 signaling promotes lymphangiogenesis, but how this pathway is affected in diabetes remains poorly understood. We previously demonstrated that...
5.
Pena A, Kobir A, Goncharov D, Goda A, Kudryashova T, Ray A, et al.
Am J Respir Cell Mol Biol
. 2017 Jul;
57(5):615-625.
PMID: 28679058
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling, increased pulmonary artery (PA) pressure, right-heart afterload and death. Mechanistic target of rapamycin (mTOR) promotes smooth muscle cell proliferation, survival,...
6.
Kudryashova T, Goncharov D, Pena A, Kelly N, Vanderpool R, Baust J, et al.
Am J Respir Crit Care Med
. 2016 Apr;
194(7):866-877.
PMID: 27119551
Rationale: Enhanced proliferation and impaired apoptosis of pulmonary arterial vascular smooth muscle cells (PAVSMCs) are key pathophysiologic components of pulmonary vascular remodeling in pulmonary arterial hypertension (PAH). Objectives: To determine...
7.
Dong Y, Wu H, Rahman H, Liu Y, Pasula S, Tessneer K, et al.
J Clin Invest
. 2016 Mar;
126(4):1607.
PMID: 26999611
No abstract available.
8.
Rahman H, Wu H, Dong Y, Pasula S, Wen A, Sun Y, et al.
Circ Res
. 2016 Feb;
118(6):957-969.
PMID: 26879230
Rationale: We previously reported that vascular endothelial growth factor (VEGF)-induced binding of VEGF receptor 2 (VEGFR2) to epsins 1 and 2 triggers VEGFR2 degradation and attenuates VEGF signaling. The epsin...
9.
Dong Y, Wu H, Rahman H, Liu Y, Pasula S, Tessneer K, et al.
J Clin Invest
. 2015 Nov;
125(12):4349-64.
PMID: 26571402
Tumor angiogenesis is critical for cancer progression. In multiple murine models, endothelium-specific epsin deficiency abrogates tumor progression by shifting the balance of VEGFR2 signaling toward uncontrolled tumor angiogenesis, resulting in...
10.
Chang B, Tessneer K, McManus J, Liu X, Hahn S, Pasula S, et al.
Nat Commun
. 2015 Apr;
6:6380.
PMID: 25871009
Uncontrolled canonical Wnt signalling supports colon epithelial tumour expansion and malignant transformation. Understanding the regulatory mechanisms involved is crucial for elucidating the pathogenesis of and will provide new therapeutic targets...