B U Bradford
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Explore the profile of B U Bradford including associated specialties, affiliations and a list of published articles.
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61
Citations
2179
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Recent Articles
1.
Wheeler M, Kono H, Yin M, Nakagami M, Uesugi T, Arteel G, et al.
Free Radic Biol Med
. 2001 Dec;
31(12):1544-9.
PMID: 11744328
Considerable evidence for a role of Kupffer cells in alcoholic liver disease has accumulated and they have recently been shown to be a predominant source of free radicals. Several approaches...
2.
Uesugi T, Froh M, Arteel G, Bradford B, Gabele E, Wheeler M, et al.
Hepatology
. 2001 Dec;
34(6):1149-57.
PMID: 11732004
Chronic alcohol administration increases gut-derived endotoxin in the portal blood, which activates Kupffer cells through nuclear factor kappaB (NF-kappaB) to produce toxic mediators such as proinflammatory cytokines, leading to liver...
3.
Yin M, Gabele E, Wheeler M, Connor H, Bradford B, Dikalova A, et al.
Hepatology
. 2001 Oct;
34(5):935-42.
PMID: 11679964
Tumor necrosis factor alpha (TNF-alpha) and free radicals are produced in early alcohol-induced liver injury. Recently, pathology caused by alcohol was blocked nearly completely in tumor necrosis factor alpha receptor...
4.
Li X, Bradford B, Wheeler M, Stimpson S, Pink H, Brodie T, et al.
Infect Immun
. 2001 Aug;
69(9):5883-91.
PMID: 11500467
Peptidoglycan polysaccharide (PG-PS) is a primary structural component of bacterial cell walls and causes rheumatoid-like arthritis in rats. Recently, glycine has been shown to be a potential immunomodulator; therefore, the...
5.
Wheeler M, Nakagami M, Bradford B, Uesugi T, Mason R, Connor H, et al.
J Biol Chem
. 2001 Jul;
276(39):36664-72.
PMID: 11477087
Mitochondria are thought to play a major role in hepatic oxidative stress associated with alcohol-induced liver injury. Thus, the hypothesis that delivery of the mitochondrial isoform of superoxide dismutase (Mn-SOD)...
6.
Uesugi T, Froh M, Arteel G, Bradford B, Thurman R
Hepatology
. 2001 Jun;
34(1):101-8.
PMID: 11431739
Chronic alcohol administration increases gut-derived endotoxin in the portal blood, which activates Kupffer cells and causes liver injury. Mice (C3H/HeJ) with mutations in toll-like receptor 4 (TLR4) are hyporesponsive to...
7.
Rivera C, Bradford B, Hunt K, Adachi Y, Schrum L, Koop D, et al.
Am J Physiol Gastrointest Liver Physiol
. 2001 Jun;
281(1):G200-7.
PMID: 11408273
The role of Kupffer cells in CCl(4)-induced fibrosis was investigated in vivo. Male Wistar rats were treated with phenobarbital and CCl(4) for 9 wk, and a group of rats were...
8.
Tsukamoto H, Takei Y, McClain C, Hill D, Schmidt J, Deaciuc I, et al.
Alcohol Clin Exp Res
. 2001 Jun;
25(5 Suppl ISBRA):171S-181S.
PMID: 11391068
This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Hidekazu Tsukamoto and Yoshiyuki Takei. The presentations were (1) Tribute to...
9.
Kono H, Uesugi T, Froh M, Rusyn I, Bradford B, Thurman R
Am J Physiol Gastrointest Liver Physiol
. 2001 May;
280(6):G1289-95.
PMID: 11352823
To test the hypothesis that leukocyte infiltration mediated by intercellular adhesion molecule (ICAM)-1 is involved in early alcohol-induced liver injury, male wild-type or ICAM-1 knockout mice were fed a high-fat...
10.
Schemmer P, Enomoto N, Bradford B, Bunzendahl H, Raleigh J, Lemasters J, et al.
Am J Physiol Gastrointest Liver Physiol
. 2001 May;
280(6):G1076-82.
PMID: 11352799
Harvesting trauma to the graft dramatically decreases survival after liver transplantation. Since activated Kupffer cells play a role in primary nonfunction, the purpose of this study was to test the...