B Rubinfeld
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Explore the profile of B Rubinfeld including associated specialties, affiliations and a list of published articles.
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35
Citations
3593
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Recent Articles
1.
Rubinfeld B, Tice D, Polakis P
J Biol Chem
. 2001 Aug;
276(42):39037-45.
PMID: 11487578
Axin and the adenomatous polyposis coli protein (APC) interact to down-regulate the proto-oncogene beta-catenin. We show that transposition of an axin-binding site can confer beta-catenin regulatory activity to a fragment...
2.
Szeto W, Jiang W, Tice D, Rubinfeld B, Hollingshead P, Fong S, et al.
Cancer Res
. 2001 May;
61(10):4197-205.
PMID: 11358845
Genetic defects in the Wnt-1 signaling pathway contribute to human tumor progression and are especially prevalent in colorectal cancer. We screened mouse C57MG cells to isolate mRNAs induced by Wnt-1...
3.
Albala J, Franke K, McConnell I, Pak K, Folta P, Rubinfeld B, et al.
J Cell Biochem
. 2000 Nov;
80(2):187-91.
PMID: 11074586
The development of high-throughput methods for gene discovery has paved the way for the design of new strategies for genome-scale protein analysis. Lawrence Livermore National Laboratory and Onyx Pharmaceuticals, Inc.,...
4.
Polakis P, Hart M, Rubinfeld B
Adv Exp Med Biol
. 2000 Mar;
470:23-32.
PMID: 10709671
The molecular events that contribute to the progression of colon cancer are beginning to unravel. An initiating and probably obligatory event is the oncogenic activation of beta-catenin. This can come...
5.
Crawford H, Fingleton B, Goss K, Rubinfeld B, Polakis P, Matrisian L
Oncogene
. 1999 Jun;
18(18):2883-91.
PMID: 10362259
Matrilysin is a matrix metalloproteinase expressed in the tumor cells of greater than 80% of intestinal adenomas. The majority of these intestinal tumors are associated with the accumulation of beta-catenin,...
6.
Hart M, Concordet J, Lassot I, Albert I, del los Santos R, Durand H, et al.
Curr Biol
. 1999 Mar;
9(4):207-10.
PMID: 10074433
Defects in beta-catenin regulation contribute to the neoplastic transformation of mammalian cells. Dysregulation of beta-catenin can result from missense mutations that affect critical sites of phosphorylation by glycogen synthase kinase...
7.
Wong M, Rubinfeld B, Gordon J
J Cell Biol
. 1998 Jun;
141(3):765-77.
PMID: 9566975
beta-Catenin functions as a downstream component of the Wnt/Wingless signal transduction pathway and as an effector of cell-cell adhesion through its association with cadherins. To explore the in vivo effects...
8.
Hart M, de los Santos R, Albert I, Rubinfeld B, Polakis P
Curr Biol
. 1998 May;
8(10):573-81.
PMID: 9601641
Background: Inactivation of the adenomatous polyposis coli (APC) tumor suppressor protein is responsible for both inherited and sporadic forms of colon cancer. Growth control by APC may relate to its...
9.
Porfiri E, Rubinfeld B, Albert I, Hovanes K, Waterman M, Polakis P
Oncogene
. 1998 Jan;
15(23):2833-9.
PMID: 9419974
Signal transduction by beta-catenin involves its posttranslational stabilization and import to the nucleus where it interacts with transcription factors. Recent implications for beta-catenin signaling in cancer prompted us to examine...
10.
Rubinfeld B, Albert I, Porfiri E, MUNEMITSU S, Polakis P
Cancer Res
. 1997 Oct;
57(20):4624-30.
PMID: 9377578
The mutation cluster region in the APC gene defines a region of approximately 660 bp, in which the vast majority of its somatic mutations are found. These mutations disrupt the...