B R Grubb
Overview
Explore the profile of B R Grubb including associated specialties, affiliations and a list of published articles.
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Articles
59
Citations
1642
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Recent Articles
1.
Livraghi-Butrico A, Grubb B, Wilkinson K, Volmer A, Burns K, Evans C, et al.
Mucosal Immunol
. 2017 Apr;
10(3):829.
PMID: 28435155
No abstract available.
2.
Ostrowski L, Yin W, Patel M, Sechelski J, Rogers T, Burns K, et al.
Gene Ther
. 2014 Jan;
21(3):253-61.
PMID: 24451115
Primary ciliary dyskinesia (PCD) is a genetically heterogenous autosomal recessive disease in which mutations disrupt ciliary function, leading to impaired mucociliary clearance and life-long lung disease. Mouse tracheal cells with...
3.
Grubb B, ONeal W, Ostrowski L, Kreda S, Button B, Boucher R
Am J Physiol Lung Cell Mol Physiol
. 2011 Oct;
302(2):L238-47.
PMID: 22003093
The relationships between airway epithelial Cl(-) secretion-Na(+) absorption balance, airway surface liquid (ASL) homeostasis, and lung disease were investigated in selected transgenic mice. 1) To determine if transgenic overexpression of...
4.
Grubb B, Rogers T, Boucher R, Ostrowski L
Am J Physiol Cell Physiol
. 2009 Mar;
296(6):C1301-9.
PMID: 19321738
The nasal epithelium of the cystic fibrosis (CF) mouse has been used extensively in CF research because it exhibits ion transport defects similar to those of human CF airways. This...
5.
Ostrowski L, Yin W, Diggs P, Rogers T, ONeal W, Grubb B
Gene Ther
. 2007 Jul;
14(20):1492-501.
PMID: 17637798
Successful gene therapy will require that the therapeutic gene be expressed at a sufficient level in the correct cell type(s). To improve the specificity of gene transfer for cystic fibrosis...
6.
Grubb B, Rogers T, Diggs P, Boucher R, Ostrowski L
Am J Physiol Lung Cell Mol Physiol
. 2005 Sep;
290(2):L270-7.
PMID: 16155086
The ion transport defects reported for human cystic fibrosis (CF) airways are reproduced in nasal epithelia of the CF mouse. Although this tissue has been studied in vivo using the...
7.
Grubb B, Jones J, Boucher R
Am J Physiol Lung Cell Mol Physiol
. 2003 Nov;
286(3):L588-95.
PMID: 14633516
We report a novel method to measure mucociliary transport (MCT) in both the upper and lower airways of normal and CF mice. The in vivo microdialysis technique involves placing a...
8.
Randell S, Walstad L, Schwab U, Grubb B, Yankaskas J
In Vitro Cell Dev Biol Anim
. 2001 Oct;
37(8):480-9.
PMID: 11669281
We describe procedures for isolating and culturing airway epithelial cells from chronically infected human lungs. Experience in our laboratory demonstrated the need to balance pathogen eradication against antibiotic toxicity to...
9.
Tarran R, Grubb B, Parsons D, Picher M, Hirsh A, Davis C, et al.
Mol Cell
. 2001 Aug;
8(1):149-58.
PMID: 11511368
There is controversy over whether abnormalities in the salt concentration or volume of airway surface liquid (ASL) initiate cystic fibrosis (CF) airway disease. In vivo studies of CF mouse nasal...
10.
Tarran R, Grubb B, Gatzy J, Davis C, Boucher R
J Gen Physiol
. 2001 Aug;
118(2):223-36.
PMID: 11479349
Two hypotheses have been proposed recently that offer different views on the role of airway surface liquid (ASL) in lung defense. The "compositional" hypothesis predicts that ASL [NaCl] is kept...