B L Sopher
Overview
Explore the profile of B L Sopher including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
1008
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0
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Recent Articles
1.
La Spada A, Fu Y, Sopher B, Libby R, Wang X, Li L, et al.
Neuron
. 2001 Oct;
31(6):913-27.
PMID: 11580893
Spinocerebellar ataxia type 7 (SCA7) is an autosomal dominant disorder caused by a CAG repeat expansion. To determine the mechanism of neurotoxicity, we produced transgenic mice and observed a cone-rod...
2.
Sopher B, Koszdin K, McClain M, Myrick S, Martinez R, Smith A, et al.
Cytogenet Cell Genet
. 2001 Jul;
93(1-2):117-23.
PMID: 11474193
The synuclein family of proteins is a group of primarily brain-expressed polypeptides that show a high degree of amino acid conservation. alpha-Synuclein is the best known of the synuclein family,...
3.
Sopher B, Myrick S, Hong J, Smith A, La Spada A
Gene
. 2001 Feb;
261(2):383-90.
PMID: 11167027
Production of mouse models of inherited neurodegenerative diseases is an important step towards understanding the mechanism of neurotoxicity and for testing potential therapies. We are interested in creating a mouse...
4.
Kinoshita Y, Jarell A, Flaman J, Foltz G, Schuster J, Sopher B, et al.
J Biol Chem
. 2000 Nov;
276(9):6656-65.
PMID: 11071894
Using a culture model of glial tumorigenesis, we identified a novel gene that was up-regulated in malignant mouse astrocytes following the loss of p53. The gene represents the murine homologue...
5.
Guo Q, Sebastian L, Sopher B, Miller M, Glazner G, Ware C, et al.
Proc Natl Acad Sci U S A
. 1999 Mar;
96(7):4125-30.
PMID: 10097174
Although an excitotoxic mechanism of neuronal injury has been proposed to play a role in chronic neurodegenerative disorders such as Alzheimer's disease, and neurotrophic factors have been put forward as...
6.
Guo Q, Sebastian L, Sopher B, Miller M, Ware C, Martin G, et al.
J Neurochem
. 1999 Feb;
72(3):1019-29.
PMID: 10037473
Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene. Overexpression of PS1 mutations in cultured PC12 cells increases their vulnerability to apoptosis-induced...
7.
Guo Q, Fu W, Sopher B, Miller M, Ware C, Martin G, et al.
Nat Med
. 1999 Jan;
5(1):101-6.
PMID: 9883847
Excitotoxicity, a form of neuronal injury in which excessive activation of glutamate receptors results in cellular calcium overload, has been implicated in the pathogenesis of Alzheimer disease (AD), although direct...
8.
Gray M, Shen J, Blank A, Sopher B, Martin G, Oshima J, et al.
Nat Genet
. 1997 Sep;
17(1):100-3.
PMID: 9288107
Werner syndrome (WS) is an uncommon autosomal recessive disorder characterized by premature aging. The clinical manifestations of WS, including atherosclerosis and osteoporosis, appear early in adulthood, and death in the...
9.
Guo Q, Sopher B, Furukawa K, Pham D, Robinson N, Martin G, et al.
J Neurosci
. 1997 Jun;
17(11):4212-22.
PMID: 9151738
Most autosomal dominant inherited forms of early onset Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS-1) gene on chromosome 14. PS-1 is an integral membrane protein with...
10.
Guo Q, Furukawa K, Sopher B, Pham D, Xie J, Robinson N, et al.
Neuroreport
. 1996 Dec;
8(1):379-83.
PMID: 9051814
Mutations in the presenilin-1 (PS-1) gene on chromosome 14 are linked to autosomal dominant early-onset Alzheimer's disease. The amino acid sequence of PS-1 predicts an integral membrane protein and immunocytochemical...