C B Ware
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Explore the profile of C B Ware including associated specialties, affiliations and a list of published articles.
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24
Citations
1628
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Recent Articles
1.
Briggs S, Ware C, Sharma K, Davis S, Lalumiere R, Parent M
Neurobiol Learn Mem
. 2021 Jun;
183:107478.
PMID: 34116139
Research involving human participants indicates that memories of recently eaten meals limit how much is eaten during subsequent eating episodes; yet, the brain regions that mediate the inhibitory effects of...
2.
Ehnes D, Hussein A, Ware C, Mathieu J, Ruohola-Baker H
Exp Cell Res
. 2020 Feb;
389(2):111913.
PMID: 32084392
Since epigenetic modifications are a key driver for cellular differentiation, the regulation of these modifications is tightly controlled. Interestingly, recent studies have revealed metabolic regulation for epigenetic modifications in pluripotent...
3.
Mathieu J, Detraux D, Kuppers D, Wang Y, Cavanaugh C, Sidhu S, et al.
Nat Commun
. 2019 Feb;
10(1):632.
PMID: 30733432
To reveal how cells exit human pluripotency, we designed a CRISPR-Cas9 screen exploiting the metabolic and epigenetic differences between naïve and primed pluripotent cells. We identify the tumor suppressor, Folliculin(FLCN)...
4.
Ladiges W, Ware C
Curr Protoc Toxicol
. 2012 Oct;
Chapter 1:Unit1.3.
PMID: 23045021
Transgenic animals are a powerful tool in the exploration of the interaction of specific genes with the environment and/or toxins to understand the relation between biochemical and metabolic pathways and...
5.
Feng R, Rampon C, Tang Y, Shrom D, Jin J, Kyin M, et al.
Neuron
. 2001 Dec;
32(5):911-26.
PMID: 11738035
To examine the in vivo function of presenilin-1 (PS1), we selectively deleted the PS1 gene in excitatory neurons of the adult mouse forebrain. These conditional knockout mice were viable and...
6.
La Spada A, Fu Y, Sopher B, Libby R, Wang X, Li L, et al.
Neuron
. 2001 Oct;
31(6):913-27.
PMID: 11580893
Spinocerebellar ataxia type 7 (SCA7) is an autosomal dominant disorder caused by a CAG repeat expansion. To determine the mechanism of neurotoxicity, we produced transgenic mice and observed a cone-rod...
7.
Wang L, Ogburn C, Ware C, Ladiges W, Youssoufian H, Martin G, et al.
Genetics
. 2000 Jan;
154(1):357-62.
PMID: 10628995
Mutations at the Werner helicase locus (WRN) are responsible for the Werner syndrome (WS). WS patients prematurely develop an aged appearance and various age-related disorders. We have generated transgenic mice...
8.
Barasch J, Yang J, Ware C, Taga T, Yoshida K, Erdjument-Bromage H, et al.
Cell
. 1999 Nov;
99(4):377-86.
PMID: 10571180
Inductive signals cause conversion of mesenchyme into epithelia during the formation of many organs. Yet a century of study has not revealed the inducing molecules. Using a standard model of...
9.
Guo Q, Sebastian L, Sopher B, Miller M, Glazner G, Ware C, et al.
Proc Natl Acad Sci U S A
. 1999 Mar;
96(7):4125-30.
PMID: 10097174
Although an excitotoxic mechanism of neuronal injury has been proposed to play a role in chronic neurodegenerative disorders such as Alzheimer's disease, and neurotrophic factors have been put forward as...
10.
Guo Q, Sebastian L, Sopher B, Miller M, Ware C, Martin G, et al.
J Neurochem
. 1999 Feb;
72(3):1019-29.
PMID: 10037473
Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene. Overexpression of PS1 mutations in cultured PC12 cells increases their vulnerability to apoptosis-induced...