B H Cochran
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Explore the profile of B H Cochran including associated specialties, affiliations and a list of published articles.
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32
Citations
2260
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Recent Articles
1.
Colpoys W, Cochran B, Carducci T, Thorpe C
Cell Signal
. 2005 Mar;
17(7):891-9.
PMID: 15763431
Shiga toxins (Stxs) cause irreversible damage to eukaryotic ribosomes, yet cellular intoxication of intestinal epithelial cells (IECs) results in increased synthesis of selected proteins, notably cytokines. How mRNA translation is...
2.
Kim D, Cochran B
Mol Cell Biol
. 2001 Apr;
21(10):3387-97.
PMID: 11313464
TFII-I is a transcription factor that shuttles between the cytoplasm and nucleus and is regulated by serine and tyrosine phosphorylation. Tyrosine phosphorylation of TFII-I can be regulated in a signal-dependent...
3.
Simon A, Vikis H, Stewart S, Fanburg B, Cochran B, Guan K
Science
. 2000 Oct;
290(5489):144-7.
PMID: 11021801
The signal transducers and activators of transcription (STAT) transcription factors become phosphorylated on tyrosine and translocate to the nucleus after stimulation of cells with growth factors or cytokines. We show...
4.
Kim D, Cochran B
Mol Cell Biol
. 2000 Jan;
20(4):1140-8.
PMID: 10648599
We have previously shown that TFII-I enhances transcriptional activation of the c-fos promoter through interactions with upstream elements in a signal-dependent manner. Here we demonstrate that activated Ras and RhoA...
5.
Kotecki M, Reddy P, Cochran B
Exp Cell Res
. 1999 Oct;
252(2):273-80.
PMID: 10527618
Mammalian somatic cells are usually diploid. Occasional rare human tumors have been shown to have a hypodiploid karyotype. We have isolated a near-haploid subclone (P1-55) from a heterogeneous human leukemia...
6.
Grammatikakis N, Lin J, Grammatikakis A, Tsichlis P, Cochran B
Mol Cell Biol
. 1999 Feb;
19(3):1661-72.
PMID: 10022854
Genetic screens in Drosophila have identified p50(cdc37) to be an essential component of the sevenless receptor/mitogen-activated kinase protein (MAPK) signaling pathway, but neither the function nor the target of p50(cdc37)...
7.
Simon A, Rai U, Fanburg B, Cochran B
Am J Physiol
. 1998 Dec;
275(6):C1640-52.
PMID: 9843726
Reactive oxygen species (ROS) play an important role in the pathogenesis of many human diseases, including the acute respiratory distress syndrome, Parkinson's disease, pulmonary fibrosis, and Alzheimer's disease. In mammalian...
8.
Silverstein A, Grammatikakis N, Cochran B, Chinkers M, Pratt W
J Biol Chem
. 1998 Aug;
273(32):20090-5.
PMID: 9685350
Several protein kinases (e.g. pp60(src), v-Raf) exist in heterocomplexes with hsp90 and a 50-kDa protein that is the mammalian homolog of the yeast cell cycle control protein Cdc37. In contrast,...
9.
Kim D, Cheriyath V, Roy A, Cochran B
Mol Cell Biol
. 1998 Jun;
18(6):3310-20.
PMID: 9584171
The transcription factor TFII-I was initially isolated as a factor that can bind to initiator elements in core promoters. Recent evidence suggests that TFII-I may also have a role in...
10.
Meyer D, Campbell G, Cochran B, Argetsinger L, Larner A, Finbloom D, et al.
J Biol Chem
. 1994 Feb;
269(7):4701-4.
PMID: 7508925
Signaling mechanisms leading to regulation of gene transcription by growth hormone (GH) and other molecules that signal via the cytokine receptor family have been elusive. Based upon recent findings that...