B D Bennett
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Explore the profile of B D Bennett including associated specialties, affiliations and a list of published articles.
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52
Citations
3015
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Recent Articles
11.
Bennett B, Denis P, Haniu M, Teplow D, Kahn S, Louis J, et al.
J Biol Chem
. 2000 Aug;
275(48):37712-7.
PMID: 10956649
The novel transmembrane aspartic protease BACE (for Beta-site APP Cleaving Enzyme) is the beta-secretase that cleaves amyloid precursor protein to initiate beta-amyloid formation. As such, BACE is a prime therapeutic...
12.
Haniu M, Denis P, Young Y, Mendiaz E, Fuller J, Hui J, et al.
J Biol Chem
. 2000 Jul;
275(28):21099-106.
PMID: 10887202
The cerebral deposition of amyloid beta-peptide is an early and critical feature of Alzheimer's disease. Amyloid beta-peptide is released from the amyloid precursor protein by the sequential action of two...
13.
Zamborelli T, Dodson W, Harding B, Zhang J, Bennett B, Lenz D, et al.
J Pept Res
. 2000 Jun;
55(5):359-71.
PMID: 10863933
The 52-residue alpha/beta chimera of the epidermal growth factor-like domain in neu differentiation factor (NDFealpha/beta) has been synthesized and folded to form a three disulfide bridge (Cys182-Cys196, Cys190-Cys210, Cys212-Cys221) containing...
14.
Bennett B, Loeloff R, Louis J, Curran E, Citron M, Vassar R
J Biol Chem
. 2000 Apr;
275(27):20647-51.
PMID: 10749877
Beta-site amyloid precursor protein cleaving enzyme (BACE) is a novel transmembrane aspartic protease that possesses all the known characteristics of the beta-secretase involved in Alzheimer's disease (Vassar, R., Bennett, B....
15.
Vassar R, Bennett B, Kahn S, Mendiaz E, Denis P, Teplow D, et al.
Science
. 1999 Oct;
286(5440):735-41.
PMID: 10531052
Cerebral deposition of amyloid beta peptide (Abeta) is an early and critical feature of Alzheimer's disease. Abeta generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two...
16.
Bennett B, Wilson C
J Neurosci
. 1999 Jun;
19(13):5586-96.
PMID: 10377365
Neostriatal cholinergic interneurons fire irregularly but tonically in vivo. The summation of relatively few depolarizing potentials and their temporal sequence are thought to underlie spike triggering and the irregularity of...
17.
Bennett B, Wilson C
J Neurosci
. 1998 Oct;
18(20):8539-49.
PMID: 9763496
Action potentials in neostriatal cholinergic interneurons recorded in vivo are triggered by summation of two or three discrete synaptic depolarizations (Wilson et al., 1990). The ability and precision with which...
18.
Bennett B, Huguenard J, Prince D
J Neurophysiol
. 1998 Apr;
79(2):937-46.
PMID: 9463454
The effect of adrenoceptor activation on pharmacologically isolated monosynaptic inhibitory postsynaptic currents (IPSCs) detected in layer V pyramidal neurons was examined by using whole cell voltage-clamp in a slice preparation...
19.
Niswender K, Postic C, Jetton T, Bennett B, Piston D, Efrat S, et al.
J Biol Chem
. 1997 Sep;
272(36):22564-9.
PMID: 9278410
Transgenic mice containing one or more extra copies of the entire glucokinase (GK) gene locus were generated and characterized. The GK transgene, an 83-kilobase pair mouse genomic DNA fragment containing...
20.
Bennett B, Huguenard J, Prince D
J Neurophysiol
. 1997 Jul;
78(1):561-6.
PMID: 9242307
At inhibitory synapses in the mature neocortex and hippocampus in vitro, spontaneous action-potential-dependent and -independent release of gamma-aminobutyric acid (GABA) activates postsynaptic GABA(A) receptors but not pre- or postsynaptic GABA(B)...