J C Louis
Overview
Explore the profile of J C Louis including associated specialties, affiliations and a list of published articles.
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76
Citations
3207
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Recent Articles
1.
Louis J, Basset P, Revel M, Vincendon G, Zwiller J
Neurochem Int
. 2010 May;
18(1):131-5.
PMID: 20504686
Purified soluble guanylate cyclase from rat brain was found to be directly activated by arachidonic acid. Arachidonic acid hydroperoxides, obtained by the action of lipoxygenase, were inhibitory. An inhibition of...
2.
3.
Louis J
Drug Discov Today
. 2003 Feb;
8(3):100-1.
PMID: 12568772
Gene-mapping studies that look for complex traits among human populations have deepened our understanding of disease causes, but do they hold promise for identifying drug targets?
4.
Zajic G, HENLEY C, Louis J, Nicolson M, Magal E
Hear Res
. 2001 Aug;
159(1-2):125-31.
PMID: 11520640
Immunophilin FK binding protein-12 (FKBP-12), the soluble receptor for the immunosuppressant drug FK506, is involved in a number of neuronal activities including increased nerve regeneration in the peripheral nervous system...
5.
Luo Y, Bolon B, Kahn S, Bennett B, Denis P, Fan W, et al.
Nat Neurosci
. 2001 Feb;
4(3):231-2.
PMID: 11224535
No abstract available.
6.
Bennett B, Denis P, Haniu M, Teplow D, Kahn S, Louis J, et al.
J Biol Chem
. 2000 Aug;
275(48):37712-7.
PMID: 10956649
The novel transmembrane aspartic protease BACE (for Beta-site APP Cleaving Enzyme) is the beta-secretase that cleaves amyloid precursor protein to initiate beta-amyloid formation. As such, BACE is a prime therapeutic...
7.
Biere A, Wood S, Wypych J, Steavenson S, Jiang Y, Anafi D, et al.
J Biol Chem
. 2000 Aug;
275(44):34574-9.
PMID: 10942772
Parkinson's disease (PD) is a neurodegenerative disorder that is pathologically characterized by the presence of intracytoplasmic Lewy bodies. Recently, two point mutations in alpha-synuclein were found to be associated with...
8.
Kuang R, Hever G, Zajic G, Yan Q, Collins F, Louis J, et al.
Ann N Y Acad Sci
. 2000 Jun;
884:270-91.
PMID: 10842600
Sensorineural hearing loss results from the degeneration of hair cells and/or auditory neurons in the cochlea of the inner ear. BDNF and NT-3 were shown to support survival of auditory...
9.
Bennett B, Loeloff R, Louis J, Curran E, Citron M, Vassar R
J Biol Chem
. 2000 Apr;
275(27):20647-51.
PMID: 10749877
Beta-site amyloid precursor protein cleaving enzyme (BACE) is a novel transmembrane aspartic protease that possesses all the known characteristics of the beta-secretase involved in Alzheimer's disease (Vassar, R., Bennett, B....
10.
Vassar R, Bennett B, Kahn S, Mendiaz E, Denis P, Teplow D, et al.
Science
. 1999 Oct;
286(5440):735-41.
PMID: 10531052
Cerebral deposition of amyloid beta peptide (Abeta) is an early and critical feature of Alzheimer's disease. Abeta generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two...