B A Donahue
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Explore the profile of B A Donahue including associated specialties, affiliations and a list of published articles.
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16
Citations
661
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Recent Articles
1.
Harding T, Koprivnikar K, Tu G, Zayek N, Lew S, Subramanian A, et al.
Gene Ther
. 2004 Jan;
11(2):204-13.
PMID: 14712305
Previous experiments have demonstrated the stable expression of factor IX (FIX) protein in mice and canine models of hemophilia B following portal vein gene transfer with a recombinant adeno-associated virus...
2.
Szczypka M, Kwok K, Brot M, Marck B, Matsumoto A, Donahue B, et al.
Neuron
. 2001 Jun;
30(3):819-28.
PMID: 11430814
Dopamine-deficient (DD) mice cannot synthesize dopamine (DA) in dopaminergic neurons due to selective inactivation of the tyrosine hydroxylase gene in those neurons. These mice become hypoactive and hypophagic and die...
3.
Donahue B, McArthur J, Spratt S, Bohl D, Lagarde C, Sanchez L, et al.
J Gene Med
. 2000 Mar;
1(1):31-42.
PMID: 10738583
Background: Recombinant adeno-associated viral (rAAV) vectors are capable of long-term expression of secreted and intracellular proteins following delivery to muscle, liver, and the central nervous system. In this study, we...
4.
Moskalenko M, Chen L, Van Roey M, Donahue B, Snyder R, McArthur J, et al.
J Virol
. 2000 Jan;
74(4):1761-6.
PMID: 10644347
Recombinant adeno-associated virus type 2 (AAV) is a common vector used in human gene therapy protocols. We characterized the humoral immune response to AAV and observed that 80% of normal...
5.
Szczypka M, Mandel R, Donahue B, Snyder R, Leff S, Palmiter R
Neuron
. 1999 Feb;
22(1):167-78.
PMID: 10027299
Dopamine-deficient mice (DA-/- ), lacking tyrosine hydroxylase (TH) in dopaminergic neurons, become hypoactive and aphagic and die by 4 weeks of age. They are rescued by daily treatment with L-3,4-dihydroxyphenylalanine...
6.
Snyder R, Miao C, Meuse L, Tubb J, Donahue B, Lin H, et al.
Nat Med
. 1999 Jan;
5(1):64-70.
PMID: 9883841
Hemophilia B, or factor IX deficiency, is an X-linked recessive disorder occurring in about 1 in 25,000 males. Affected individuals are at risk for spontaneous bleeding into many organs; treatment...
7.
Rendahl K, Leff S, Otten G, Spratt S, Bohl D, Van Roey M, et al.
Nat Biotechnol
. 1998 Aug;
16(8):757-61.
PMID: 9702775
Control of gene expression is important to gene therapy for purposes of both dosing and safety. In vivo regulation of gene expression was demonstrated following co-injection of two separate recombinant...
8.
Tornaletti S, Donahue B, Reines D, HANAWALT P
J Biol Chem
. 1998 Feb;
272(50):31719-24.
PMID: 9395515
We have studied the role of sequence context upon RNA polymerase II arrest by a cyclobutane pyrimidine dimer using an in vitro transcription system consisting of templates containing a specifically...
9.
Donahue B, Fuchs R, Reines D, HANAWALT P
J Biol Chem
. 1996 May;
271(18):10588-94.
PMID: 8631860
A prominent model for the mechanism of transcription-coupled DNA repair proposes that an arrested RNA polymerase directs the nucleotide excision repair complex to the transcription-blocking lesion. The specific role for...
10.
Donahue B, Yin S, Taylor J, Reines D, HANAWALT P
Proc Natl Acad Sci U S A
. 1994 Aug;
91(18):8502-6.
PMID: 8078911
A current model for transcription-coupled DNA repair is that RNA polymerase, arrested at a DNA lesion, directs the repair machinery to the transcribed strand of an active gene. To help...