R J Mandel
Overview
Explore the profile of R J Mandel including associated specialties, affiliations and a list of published articles.
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Articles
47
Citations
3500
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Recent Articles
1.
Gombash S, Manfredsson F, Mandel R, Collier T, Fischer D, Kemp C, et al.
Gene Ther
. 2014 May;
21(7):682-93.
PMID: 24807806
Intrastriatal injection of recombinant adeno-associated viral vector serotype 2/1 (rAAV2/1) to overexpress the neurotrophic factor pleiotrophin (PTN) provides neuroprotection for tyrosine hydroxylase immunoreactive (THir) neurons in the substantia nigra pars...
2.
Scholz S, Mandel R, Fernandez H, Foote K, Rodriguez R, Barton E, et al.
Eur J Neurol
. 2006 Nov;
13(12):1298-301.
PMID: 17116211
In the last decade, major breakthroughs in the understanding of genetic contributions to Parkinson's disease (PD) have been achieved. Recently, mutations in LRRK2, encoding dardarin, have been found to be...
3.
Manfredsson F, Lewin A, Mandel R
Gene Ther
. 2005 Nov;
13(6):517-24.
PMID: 16267570
Parkinson's disease is a prevalent progressive degenerative disorder of the elderly. There is a current need for novel therapeutic strategies because the standard levodopa pharmacotherapy is only temporarily efficacious. Recently,...
4.
Irani B, Xiang Z, Moore M, Mandel R, Haskell-Luevano C
Biochem Biophys Res Commun
. 2004 Dec;
326(3):638-44.
PMID: 15596147
The melanocortin system is involved in hypothalamic regulation of energy homeostasis. The melanocortin-4 receptor (MC4R) has been linked to both obesity and reproductive dysfunction. Deletion of the MC4R from the...
5.
Englund U, Ericson C, Rosenblad C, Mandel R, Trono D, Wictorin K, et al.
Neuroreport
. 2001 Feb;
11(18):3973-7.
PMID: 11192612
A major obstacle in ex vivo gene transfer has been the loss of transgene expression soon after implantation of the grafted transduced cells. Recently, a lentiviral vector system has been...
6.
Bjorklund A, Kirik D, Rosenblad C, Georgievska B, Lundberg C, Mandel R
Brain Res
. 2000 Dec;
886(1-2):82-98.
PMID: 11119690
During the last few years, recombinant viral vectors derived from adenovirus (Ad), adeno-associated virus (AAV) or lentivirus (LV) have been developed into highly effective vehicles for gene transfer to the...
7.
Klein R, Mandel R, Muzyczka N
Adv Virus Res
. 2000 Oct;
55:507-28.
PMID: 11050954
No abstract available.
8.
Chen E, Kallwitz E, Leff S, Cochran E, Mufson E, Kordower J, et al.
J Comp Neurol
. 2000 Oct;
426(4):534-48.
PMID: 11027397
Guanosine triphosphate cyclohydrolase I (GTPCHI) is a critical enzyme in catecholamine function and is rate limiting for the synthesis of the catecholamine co-factor tetrahydrobiopterin. The present study assessed the distribution...
9.
Kirik D, Rosenblad C, Bjorklund A, Mandel R
J Neurosci
. 2000 Jun;
20(12):4686-700.
PMID: 10844038
Previous studies have used recombinant adeno-associated viral (rAAV) vectors to deliver glial cell line-derived neurotrophic factor (GDNF) in the substantia nigra to protect the nigral dopamine (DA) neurons from 6-hydroxydopamine-induced...
10.
Mandel R
Exp Neurol
. 2000 Feb;
161(1):212-9.
PMID: 10683287
Currently, reduction of apomorphine-induced rotational behavior in the 6-hydroxydopamine (6-OHDA) lesioned rat is the most utilized drug-induced paradigm for assessing functional efficacy in a rat model of Parkinson's disease (PD)....