Alpha 2.0
Login Register
» Authors » Ayumu Sato

Ayumu Sato

Explore the profile of Ayumu Sato including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 22
Followers 0
Related Specialties
Chemistry
Biochemistry
Pharmacology
Top 10 Co-Authors
Junya Shirai
Satoshi Yamamoto
Mitsunori Kono
Robert Skene
Isaac Hoffman
Masashi Yamasaki
Yoshiyuki Fukase
Atsuko Ochida
Yoshihide Tomata
Hideyuki Nakagawa
Published In
J Med Chem
Bioorg Med Chem
ChemMedChem
Eur J Med Chem
Affiliations
Soon will be listed here.
Recent Articles
1.
Design and Synthesis of Conformationally Constrained RORγt Inverse Agonists
Sato A, Fukase Y, Kono M, Ochida A, Oda T, Sasaki Y, et al.
ChemMedChem . 2019 Oct; 14(22):1917-1932. PMID: 31659845
Retinoic-acid-related orphan receptor γt (RORγt) inverse agonists could be used for the treatment of autoimmune diseases. Previously, we reported a novel quinazolinedione 1 a with a flexible linear linker as...
2.
Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Inverse Agonist to RORγt Agonist
Yukawa T, Nara Y, Kono M, Sato A, Oda T, Takagi T, et al.
J Med Chem . 2019 Jan; 62(3):1167-1179. PMID: 30652849
Retinoic acid receptor-related orphan receptor γt (RORγt) agonists are expected to provide a novel class of immune-activating anticancer drugs via activation of Th17 cells and Tc17 cells. Herein, we describe...
3.
Identification of novel quinazolinedione derivatives as RORγt inverse agonist
Fukase Y, Sato A, Tomata Y, Ochida A, Kono M, Yonemori K, et al.
Bioorg Med Chem . 2018 Jan; 26(3):721-736. PMID: 29342416
Novel small molecules were synthesized and evaluated as retinoic acid receptor-related orphan receptor-gamma t (RORγt) inverse agonists for the treatment of inflammatory and autoimmune diseases. A hit compound, 1, was...
4.
Discovery of orally efficacious RORγt inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds
Shirai J, Tomata Y, Kono M, Ochida A, Fukase Y, Sato A, et al.
Bioorg Med Chem . 2017 Dec; 26(2):483-500. PMID: 29262987
A series of novel phenylglycinamides as retinoic acid receptor-related orphan receptor-gamma t (RORγt) inverse agonists were discovered through optimization of a high-throughput screen hit 1. (R)-N-(2-((3,5-Difluoro-4-(trimethylsilyl)phenyl) amino)-1-(4-methoxyphenyl)-2-oxoethyl)-3-hydroxy-N-methylisoxazole-5-carboxamide (22) was identified...
5.
Identification of 3,4-dihydro-2H-thiochromene 1,1-dioxide derivatives with a phenoxyethylamine group as highly potent and selective α adrenoceptor antagonists
Sakauchi N, Furukawa H, Shirai J, Sato A, Kuno H, Saikawa R, et al.
Eur J Med Chem . 2017 Aug; 139:114-127. PMID: 28800452
A series of phenoxyethylamine derivatives was designed and synthesized to discover potent and selective human α adrenoceptor (α adrenergic receptor; α-AR) antagonists. Compound 7 was taken from our internal compound...
6.
Discovery of 5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide (TAK-259) as a Novel, Selective, and Orally Active α1D Adrenoceptor Antagonist with Antiurinary Frequency Effects: Reducing Human...
Sakauchi N, Kohara Y, Sato A, Suzaki T, Imai Y, Okabe Y, et al.
J Med Chem . 2016 Mar; 59(7):2989-3002. PMID: 26954848
A novel structural class of iminopyridine derivative 1 was identified as a potent and selective human α1D adrenoceptor (α1D adrenergic receptor; α1D-AR) antagonist against α1A- and α1B-AR through screening of...