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Autumn McKnite

Explore the profile of Autumn McKnite including associated specialties, affiliations and a list of published articles. Areas
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Articles 12
Citations 52
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Recent Articles
1.
Chevalier A, McKnite A, Whelan A, Imburgia C, Rower J, Watt K, et al.
Perfusion . 2024 Nov; :2676591241297401. PMID: 39499963
Background: Azithromycin and methylprednisolone are two medications that are commonly used in patients who require ECMO support. Unfortunately, ECMO support can decrease drug concentrations through adsorption to circuit components. Such...
2.
Dubinsky S, Hamadeh A, Imburgia C, McKnite A, Hunt J, Wong K, et al.
Clin Pharmacokinet . 2024 Sep; 63(9):1343-1356. PMID: 39331235
Background And Objective: Because of the pathophysiological changes associated with critical illness and the use of extracorporeal life support (ECLS) such as continuous renal replacement therapy (CRRT) and extracorporeal membrane...
3.
Chevalier A, Hunt J, Whelan A, McKnite A, Watt K, Green D
J Extra Corpor Technol . 2024 Sep; 56(3):101-107. PMID: 39303131
Background: Patients supported with extracorporeal life support (ECLS) circuits such as ECMO and CRRT often require high doses of sedatives and analgesics, including ketamine and dexmedetomidine. Concentrations of many medications...
4.
Yellepeddi V, Hunt J, Green D, McKnite A, Whelan A, Watt K
CPT Pharmacometrics Syst Pharmacol . 2024 Jul; 13(9):1542-1553. PMID: 39033462
Extracorporeal membrane oxygenation (ECMO) is a cardiopulmonary bypass device commonly used to treat cardiac arrest in children. The American Heart Association guidelines for cardiopulmonary resuscitation (CPR) and emergency cardiovascular care...
5.
Honeycutt C, McDaniel C, McKnite A, Hunt J, Whelan A, Green D, et al.
J Extra Corpor Technol . 2023 Dec; 55(4):159-166. PMID: 38099629
Background: Meropenem is a broad-spectrum carbapenem-type antibiotic commonly used to treat critically ill patients infected with extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. As many of these patients require extracorporeal membrane oxygenation (ECMO)...
6.
Rower J, McKnite A, Hong B, Daly K, Hope K, Cabrera A, et al.
Pharmacotherapy . 2023 Jun; 43(7):650-658. PMID: 37328271
Study Objective: The immunosuppressant tacrolimus is a first-line agent to prevent graft rejection following pediatric heart transplant; however, it suffers from extensive inter-patient variability and a narrow therapeutic window. Personalized...
7.
McKnite A, Kim H, Silva J, Christian J
Dev Dyn . 2023 Feb; 252(6):761-769. PMID: 36825302
Background: The Bone morphogenetic protein 4 (BMP4) precursor protein is cleaved at two sites to generate an active ligand and inactive prodomain. The ligand and prodomain form a noncovalent complex...
8.
Green D, Watt K, Fish D, McKnite A, Kelley W, Bensimhon A
J Extra Corpor Technol . 2023 Feb; 54(3):212-222. PMID: 36742220
Extracorporeal life support (ECLS) devices are lifesaving for critically ill patients with multi-organ dysfunction. Despite this, patients supported with ECLS are at high risk for ECLS-related complications, including nosocomial infections,...
9.
Kim H, Neugebauer J, McKnite A, Tilak A, Christian J
Elife . 2019 Oct; 8. PMID: 31566563
BMP7/BMP2 or BMP7/BMP4 heterodimers are more active than homodimers in vitro, but it is not known whether these heterodimers signal in vivo. To test this, we generated knock in mice...
10.
Kim H, McKnite A, Christian J
Methods Mol Biol . 2018 Nov; 1891:115-133. PMID: 30414129
Bone morphogenetic proteins (Bmps) are synthesized as inactive precursors that are cleaved to generate active ligands, along with prodomain fragments that can modulate growth factor activity. Here we provide three...