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Autumn Brown Gandt

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Articles 7
Citations 599
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Recent Articles
1.
Mugengana A, Vita N, Brown Gandt A, Moran K, Agyapong G, Sharma L, et al.
ACS Infect Dis . 2021 Jan; 7(5):1044-1058. PMID: 33471519
The successful treatment of infections is becoming increasingly difficult due to the rise of resistance against current broad spectrum triple therapy regimens. In the search for narrow-spectrum agents against ,...
2.
Mroue N, Arya A, Brown Gandt A, Russell C, Han A, Gavrish E, et al.
Antimicrob Agents Chemother . 2019 Oct; 64(1). PMID: 31611348
It is often difficult to cure endocarditis, osteomyelitis, and device-associated infections caused by Gram-positive pathogens, despite therapy with clinically appropriate antibiotics. This may be due to antibiotic tolerance or resistance...
3.
Brown Gandt A, Griffith E, Lister I, Billings L, Han A, Tangallapally R, et al.
Antimicrob Agents Chemother . 2018 May; 62(8). PMID: 29784838
Antibiotics with novel bactericidal mechanisms of action are urgently needed. The antibiotic acyldepsipeptide 4 (ADEP4) activates the ClpP protease and causes cells to self-digest. The effects of ADEP4 and ClpP...
4.
Shan Y, Brown Gandt A, Rowe S, Deisinger J, Conlon B, Lewis K
mBio . 2017 Feb; 8(1). PMID: 28174313
Importance: Persisters are a subpopulation of antibiotic-tolerant cells responsible for the recalcitrance of chronic infections. Our current understanding of persister formation is primarily based on studies of E. coli The...
5.
Conlon B, Rowe S, Brown Gandt A, Nuxoll A, Donegan N, Zalis E, et al.
Nat Microbiol . 2016 Aug; 1:16051. PMID: 27572649
Persisters are dormant phenotypic variants of bacterial cells that are tolerant to killing by antibiotics(1). Persisters are associated with chronic infections and antibiotic treatment failure(1-3). In Escherichia coli, toxin-antitoxin modules...
6.
Homma T, Nuxoll A, Brown Gandt A, Ebner P, Engels I, Schneider T, et al.
Antimicrob Agents Chemother . 2016 Aug; 60(11):6510-6517. PMID: 27550357
Teixobactin represents the first member of a newly discovered class of antibiotics that act through inhibition of cell wall synthesis. Teixobactin binds multiple bactoprenol-coupled cell wall precursors, inhibiting both peptidoglycan...
7.
Conlon B, Rowe S, Brown Gandt A, Nuxoll A, Donegan N, Zalis E, et al.
Nat Microbiol . 2016 Jul; 1. PMID: 27398229
Persisters are dormant phenotypic variants of bacterial cells that are tolerant to killing by antibiotics. Persisters are associated with chronic infections and antibiotic treatment failure. In , toxin/antitoxin (TA) modules...