Austin L Hughes
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Explore the profile of Austin L Hughes including associated specialties, affiliations and a list of published articles.
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186
Citations
3976
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Recent Articles
11.
Dudley D, Bailey A, Mehta S, Hughes A, Kirk G, Westergaard R, et al.
Retrovirology
. 2014 Dec;
11:122.
PMID: 25533166
Background: Viral resistance to antiretroviral therapy threatens our best methods to control and prevent HIV infection. Current drug resistance genotyping methods are costly, optimized for subtype B virus, and primarily...
12.
Hughes A
J Insect Sci
. 2014 Dec;
14.
PMID: 25502029
Phylogenetic analysis of insect innexins supported the hypothesis that six major clades of insect innexins arose by gene duplication prior to the origin of the endopterygote insects. Within one of...
13.
Nelson C, Hughes A
Infect Genet Evol
. 2014 Dec;
30:1-7.
PMID: 25481279
Next-generation sequencing (NGS) technology offers new opportunities for understanding the evolution and dynamics of viral populations within individual hosts over the course of infection. We review simple methods for estimating...
14.
Hughes A, Friedman R
Immunogenetics
. 2014 Aug;
66(11):651-61.
PMID: 25142446
In a phylogenetic analysis of vertebrate transferrins (TFs), six major clades (subfamilies) were identified: (a) S, the mammalian serotransferrins; (b) ICA, the mammalian inhibitor of carbonic anhydrase (ICA) homologs; (c)...
15.
Hughes A
Coevolution
. 2014 May;
1(1):1-7.
PMID: 24834437
Baculoviruses infecting Lepidoptera (butterflies and moths) encodes an enzyme known as ecdysosteroid UDP-glycosyltransferase (EGT), which inactivates insect host ecdysosteroid hormones, thereby preventing molt and pupation and permitting a build-up of...
16.
Hughes A
Mol Phylogenet Evol
. 2014 Mar;
76:127-33.
PMID: 24675701
Members of the aminopepidase N (APN) gene family of the insect order Lepidoptera (moths and butterflies) bind the naturally insecticidal Cry toxins produced by the bacterium Bacillus thuringiensis. Phylogenetic analysis...
17.
Bailey A, Lauck M, Weiler A, Sibley S, Dinis J, Bergman Z, et al.
PLoS One
. 2014 Mar;
9(3):e90714.
PMID: 24651479
Key biological properties such as high genetic diversity and high evolutionary rate enhance the potential of certain RNA viruses to adapt and emerge. Identifying viruses with these properties in their...
18.
Luo H, Swan B, Stepanauskas R, Hughes A, Moran M
Environ Microbiol Rep
. 2014 Mar;
6(2):167-72.
PMID: 24596290
A fundamental question in marine microbial ecology is how microbes adapt to ocean environments. Although numerically dominant populations are typically considered more successful, higher census population sizes (Nc) do not...
19.
Scholtz E, Krishnan S, Ball B, Corbin C, Moeller B, Stanley S, et al.
Proc Natl Acad Sci U S A
. 2014 Feb;
111(9):3365-70.
PMID: 24550466
One of the most widely accepted axioms of mammalian reproductive biology is that pregnancy requires the (sole) support of progesterone, acting in large measure through nuclear progesterone receptors (PRs) in...
20.
Luo H, Swan B, Stepanauskas R, Hughes A, Moran M
ISME J
. 2014 Jan;
8(7):1428-39.
PMID: 24451207
The vast majority of surface ocean bacteria are uncultivated. Compared with their cultured relatives, they frequently exhibit a streamlined genome, reduced G+C content and distinct gene repertoire. These genomic traits...