Aurelien Ginolhac
Overview
Explore the profile of Aurelien Ginolhac including associated specialties, affiliations and a list of published articles.
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37
Citations
2357
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Recent Articles
1.
Lind-Holm Mogensen F, Sousa C, Ameli C, Badanjak K, Pereira S, Muller A, et al.
J Neuroinflammation
. 2024 Jul;
21(1):174.
PMID: 39014482
Background: Specific microglia responses are thought to contribute to the development and progression of neurodegenerative diseases, including Parkinson's disease (PD). However, the phenotypic acquisition of microglial cells and their role...
2.
Gomez Ramos B, Ohnmacht J, de Lange N, Valceschini E, Ginolhac A, Catillon M, et al.
EMBO Rep
. 2024 Jan;
25(1):254-285.
PMID: 38177910
Midbrain dopaminergic neurons (mDANs) control voluntary movement, cognition, and reward behavior under physiological conditions and are implicated in human diseases such as Parkinson's disease (PD). Many transcription factors (TFs) controlling...
3.
Gavriil M, Proietto M, Paczia N, Ginolhac A, Halder R, Valceschini E, et al.
Life Sci Alliance
. 2023 Nov;
7(2).
PMID: 38011998
2-Hydroxyglutarate (2-HG) is an oncometabolite that accumulates in certain cancers. Gain-of-function mutations in isocitrate dehydrogenase lead to 2-HG accumulation at the expense of alpha-ketoglutarate. Elevated 2-HG levels inhibit histone and...
4.
Ternes D, Tsenkova M, Pozdeev V, Meyers M, Koncina E, Atatri S, et al.
Nat Metab
. 2023 Sep;
5(9):1638.
PMID: 37709964
No abstract available.
5.
Ternes D, Tsenkova M, Pozdeev V, Meyers M, Koncina E, Atatri S, et al.
Nat Metab
. 2022 Apr;
4(4):458-475.
PMID: 35437333
The gut microbiome is a key player in the immunomodulatory and protumorigenic microenvironment during colorectal cancer (CRC), as different gut-derived bacteria can induce tumour growth. However, the crosstalk between the...
6.
Del Mistro G, Riemann S, Schindler S, Beissert S, Kontermann R, Ginolhac A, et al.
Cell Death Dis
. 2022 Jan;
13(1):54.
PMID: 35022419
Despite remarkable advances in therapeutic interventions, malignant melanoma (MM) remains a life-threating disease. Following high initial response rates to targeted kinase-inhibition metastases quickly acquire resistance and present with enhanced tumor...
7.
Birck C, Ginolhac A, Pavlou M, Michelucci A, Heuschling P, Grandbarbe L
Cells
. 2021 Apr;
10(4).
PMID: 33917855
The NF-κB signaling pathway is crucial during development and inflammatory processes. We have previously shown that NF-κB activation induces dedifferentiation of astrocytes into neural progenitor cells (NPCs). Here, we provide...
8.
Kirchmeyer M, Servais F, Ginolhac A, Nazarov P, Margue C, Philippidou D, et al.
J Mol Biol
. 2020 Sep;
432(22):5902-5919.
PMID: 32950480
Cytokines orchestrate responses to pathogens and in inflammatory processes, but they also play an important role in cancer by shaping the expression levels of cytokine response genes. Here, we conducted...
9.
Shahraz A, Wissfeld J, Ginolhac A, Mathews M, Sinkkonen L, Neumann H
Glia
. 2020 Jul;
69(1):137-150.
PMID: 32721081
Repeated systemic challenge with lipopolysaccharides (LPS) can induce microglia activation and inflammatory neurodegeneration in the substantia nigra pars compacta region of mice. We now explored the role of mononuclear phagocytes...
10.
Klaus C, Hansen J, Ginolhac A, Gerard D, Gnanapragassam V, Horstkorte R, et al.
Neurobiol Aging
. 2020 Feb;
88:91-107.
PMID: 32087947
Sialic acid-binding Ig-like lectin (Siglec) receptors are linked to neurodegenerative processes, but the role of sialic acids in physiological aging is still not fully understood. We investigated the impact of...