Atefeh Lafzi
Overview
Explore the profile of Atefeh Lafzi including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
527
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0
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Recent Articles
1.
Borrelli C, Roberts M, Eletto D, Hussherr M, Fazilaty H, Valenta T, et al.
Nature
. 2024 Jul;
632(8024):411-418.
PMID: 39048831
It is estimated that only 0.02% of disseminated tumour cells are able to seed overt metastases. While this suggests the presence of environmental constraints to metastatic seeding, the landscape of...
2.
Lafzi A, Borrelli C, Baghai Sain S, Bach K, Kretz J, Handler K, et al.
Mol Syst Biol
. 2024 Jan;
20(2):98-119.
PMID: 38225383
Sequencing-based spatial transcriptomics (ST) methods allow unbiased capturing of RNA molecules at barcoded spots, charting the distribution and localization of cell types and transcripts across a tissue. While the coarse...
3.
Gurtner A, Borrelli C, Gonzalez-Perez I, Bach K, Acar I, Nunez N, et al.
Nature
. 2022 Dec;
615(7950):151-157.
PMID: 36509106
In the past decade, single-cell transcriptomics has helped to uncover new cell types and states and led to the construction of a cellular compendium of health and disease. Despite this...
4.
Mikl M, Eletto D, Nijim M, Lee M, Lafzi A, Mhamedi F, et al.
Nucleic Acids Res
. 2022 Sep;
50(18):10643-10664.
PMID: 36156153
Asymmetric subcellular mRNA localization allows spatial regulation of gene expression and functional compartmentalization. In neurons, localization of specific mRNAs to neurites is essential for cellular functioning. However, it is largely...
5.
Borrelli C, Valenta T, Handler K, Velez K, Gurtner A, Moro G, et al.
Nat Commun
. 2021 Mar;
12(1):1368.
PMID: 33649334
The homeostasis of the gut epithelium relies upon continuous renewal and proliferation of crypt-resident intestinal epithelial stem cells (IESCs). Wnt/β-catenin signaling is required for IESC maintenance, however, it remains unclear...
6.
Vizan P, Gutierrez A, Espejo I, Garcia-Montolio M, Lange M, Carretero A, et al.
Sci Adv
. 2020 Aug;
6(32):eabb2745.
PMID: 32821835
Adult hematopoietic stem cells (HSCs) are rare multipotent cells in bone marrow that are responsible for generating all blood cell types. HSCs are a heterogeneous group of cells with high...
7.
Mereu E, Lafzi A, Moutinho C, Ziegenhain C, McCarthy D, Alvarez-Varela A, et al.
Nat Biotechnol
. 2020 Jun;
38(6):747-755.
PMID: 32518403
Single-cell RNA sequencing (scRNA-seq) is the leading technique for characterizing the transcriptomes of individual cells in a sample. The latest protocols are scalable to thousands of cells and are being...
8.
Lafzi A, Moutinho C, Picelli S, Heyn H
Nat Protoc
. 2018 Nov;
13(12):2742-2757.
PMID: 30446749
Single-cell RNA sequencing is at the forefront of high-resolution phenotyping experiments for complex samples. Although this methodology requires specialized equipment and expertise, it is now widely applied in research. However,...
9.
Salzer M, Lafzi A, Berenguer-Llergo A, Youssif C, Castellanos A, Solanas G, et al.
Cell
. 2018 Nov;
175(6):1575-1590.e22.
PMID: 30415840
During aging, stromal functions are thought to be impaired, but little is known whether this stems from changes of fibroblasts. Using population- and single-cell transcriptomics, as well as long-term lineage...
10.
Lafzi A, Kazan H
PLoS One
. 2016 May;
11(5):e0155354.
PMID: 27186987
RNA-binding proteins (RBPs) play key roles in post-transcriptional regulation of mRNAs. Dysregulations in RBP-mediated mechanisms have been found to be associated with many steps of cancer initiation and progression. Despite...