Astrid S Kahnt
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Explore the profile of Astrid S Kahnt including associated specialties, affiliations and a list of published articles.
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23
Citations
263
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Recent Articles
1.
Kahnt A, Hafner A, Steinhilber D
Oncogene
. 2024 Apr;
43(18):1319-1327.
PMID: 38575760
5-Lipoxygenase (5-LO), a fatty acid oxygenase, is the central enzyme in leukotriene (LT) biosynthesis, potent arachidonic acid-derived lipid mediators released by innate immune cells, that control inflammatory and allergic responses....
2.
Kahnt A, Schebb N, Steinhilber D
Prostaglandins Other Lipid Mediat
. 2023 Mar;
166:106726.
PMID: 36878381
Specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins are formed by the consecutive action of 5-lipoxygenase (5-LO, ALOX5) and different types of arachidonic acid 12- or 15-lipoxygenases using...
3.
Gobel T, Goebel B, Hyprath M, Lamminger I, Weisser H, Angioni C, et al.
Life Sci Alliance
. 2023 Feb;
6(5).
PMID: 36849252
The leukotriene (LT) pathway is positively correlated with the progression of solid malignancies, but the factors that control the expression of 5-lipoxygenase (5-LO), the central enzyme in LT biosynthesis, in...
4.
Weisser H, Gobel T, Melissa Krishnathas G, Kreiss M, Angioni C, Surun D, et al.
Cancer Gene Ther
. 2022 Sep;
30(1):108-123.
PMID: 36114329
5-Lipoxygenase (5-LO), the central enzyme in the biosynthesis of leukotrienes, is frequently expressed in human solid malignancies even though the enzyme is not present in the corresponding healthy tissues. There...
5.
Schebb N, Kuhn H, Kahnt A, Rund K, ODonnell V, Flamand N, et al.
Front Pharmacol
. 2022 Mar;
13:838782.
PMID: 35308198
Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of arachidonic acid 12- and 15-lipoxygenating paralogues (15-LO1,...
6.
Kahnt A, Angioni C, Gobel T, Hofmann B, Roos J, Steinbrink S, et al.
Front Pharmacol
. 2022 Feb;
12:782584.
PMID: 35126121
5-Lipoxygenase (5-LO) is the key enzyme in the formation of pro-inflammatory leukotrienes (LT) which play an important role in a number of inflammatory diseases. Accordingly, 5-LO inhibitors are frequently used...
7.
Lillich F, Willems S, Ni X, Kilu W, Borkowsky C, Brodsky M, et al.
J Med Chem
. 2021 Nov;
64(23):17259-17276.
PMID: 34818007
Polypharmaceutical regimens often impair treatment of patients with metabolic syndrome (MetS), a complex disease cluster, including obesity, hypertension, heart disease, and type II diabetes. Simultaneous targeting of soluble epoxide hydrolase...
8.
Wanior M, Preuss F, Ni X, Kramer A, Mathea S, Gobel T, et al.
J Med Chem
. 2020 Nov;
63(23):14680-14699.
PMID: 33216538
Accessibility of the human genome is modulated by the ATP-driven SWI/SNF chromatin remodeling multiprotein complexes BAF (BRG1/BRM-associated factor) and PBAF (polybromo-associated BAF factor), which involves reading of acetylated histone tails...
9.
von Hegedus J, Kahnt A, Ebert R, Heijink M, Toes R, Giera M, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2020 May;
1865(9):158740.
PMID: 32447052
Inflammation is a tightly regulated process. During the past decade it has become clear that the resolution of inflammation is an active process and its dysregulation can contribute to chronic...
10.
Ebert R, Cumbana R, Lehmann C, Kutzner L, Toewe A, Ferreiros N, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2020 Mar;
1865(9):158702.
PMID: 32222425
Macrophage polarization switches during the course of inflammation along with the lipid mediators released. We investigated the lipid mediator formation in human monocyte-derived macrophages during in vitro differentiation and pathogen...