Astrid Borchert
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Explore the profile of Astrid Borchert including associated specialties, affiliations and a list of published articles.
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27
Citations
566
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Recent Articles
1.
Gundem E, Stehling S, Borchert A, Kuhn H
J Lipid Res
. 2025 Mar;
:100768.
PMID: 40044044
Lipoxygenases (ALOX) play important roles in cell differentiation and in the pathogenesis of cardio-vascular, hyperproliferative, neurodegenerative and metabolic diseases. The human genome involves six intact ALOX genes and knockout studies...
2.
Faraji P, Parandavar E, Kuhn H, Habibi-Rezaei M, Borchert A, Zahedi E, et al.
Mol Med
. 2024 Nov;
30(1):204.
PMID: 39511487
Background: Alzheimer's disease (AD) is the most common human neurodegenerative disorder worldwide. Owing to its chronic nature, our limited understanding of its pathophysiological mechanisms, and because of the lack of...
3.
Faraji P, Borchert A, Ahmadian S, Kuhn H
Antioxidants (Basel)
. 2024 Feb;
13(2).
PMID: 38397840
Ferroptosis is a special kind of programmed cell death that has been implicated in the pathogenesis of a large number of human diseases. It involves dysregulated intracellular iron metabolism and...
4.
Soria-Tiedemann M, Michel G, Urban I, Aldrovandi M, ODonnell V, Stehling S, et al.
Int J Mol Sci
. 2022 Sep;
23(17).
PMID: 36077303
Glutathione peroxidase 4 (Gpx4) and arachidonic acid 15 lipoxygenase (Alox15) are counterplayers in oxidative lipid metabolism and both enzymes have been implicated in spermatogenesis. However, the roles of the two...
5.
Rademacher M, Kuhn H, Borchert A
Int J Mol Sci
. 2021 Aug;
22(15).
PMID: 34360557
Among the eight human glutathione peroxidase isoforms, glutathione peroxidase 4 (GPX4) is the only enzyme capable of reducing complex lipid peroxides to the corresponding alcohols. In mice, corruption of the...
6.
Rademacher M, Kuhn H, Borchert A
FASEB J
. 2020 Sep;
34(11):14318-14335.
PMID: 32918502
Arachidonic acid 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes, which has previously been implicated in the maturational breakdown of intracellular organelles and plasma membrane remodeling during reticulocyte-erythrocyte transition. Conventional Alox15 mice...
7.
Borchert A, Kalms J, Roth S, Rademacher M, Schmidt A, Holzhutter H, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2018 Jun;
1863(9):1095-1107.
PMID: 29883798
Glutathione peroxidases (GPX) are anti-oxidative enzymes that reduce organic and inorganic hydroperoxides to the corresponding alcohols at the expense of reduced glutathione. The human genome involves eight GPX genes and...
8.
Brutsch S, Rademacher M, Roth S, Muller K, Eder S, Viertel D, et al.
J Biol Chem
. 2016 Sep;
291(45):23578-23588.
PMID: 27634046
Glutathione peroxidase 4 (GPX4) and arachidonic acid 15-lipoxygenase (ALOX15) are antagonizing enzymes in the metabolism of hydroperoxy lipids. In spermatoid cells and/or in the male reproductive system both enzymes are...
9.
Brutsch S, Wang C, Li L, Stender H, Neziroglu N, Richter C, et al.
Antioxid Redox Signal
. 2014 Oct;
22(4):281-93.
PMID: 25313597
Aims: Glutathione peroxidases (Gpx) and lipoxygenases (Alox) are functional counterplayers in the metabolism of hydroperoxy lipids that regulate cellular redox homeostasis. Gpx4 is a moonlighting protein that has been implicated...
10.
Fischer K, von Brunneck A, Hornung D, Denkert C, Ufer C, Schiebel H, et al.
Arch Biochem Biophys
. 2014 Mar;
547:27-36.
PMID: 24603286
Secretoglobins (SCGB), such as mammaglobin 1 (MGB1, SCGB2A2), mammaglobin 2 (MGB2, SCGB2A1) and lipophilin B (LIPB, SCGB1D2), have been related to carcinogenesis. We profiled expression of MGB1, MGB2 and LIPB...