Ashutosh Dhingra
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Explore the profile of Ashutosh Dhingra including associated specialties, affiliations and a list of published articles.
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12
Citations
436
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Recent Articles
1.
Yin J, Frick L, Scheidmann M, Liu T, Trevisan C, Dhingra A, et al.
Nat Biomed Eng
. 2024 Dec;
9(1):127-148.
PMID: 39633028
Arrayed CRISPR libraries extend the scope of gene-perturbation screens to non-selectable cell phenotypes. However, library generation requires assembling thousands of vectors expressing single-guide RNAs (sgRNAs). Here, by leveraging massively parallel...
2.
Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2
Ging K, Frick L, Schlachetzki J, Armani A, Zhu Y, Gilormini P, et al.
NPJ Parkinsons Dis
. 2024 Oct;
10(1):192.
PMID: 39438499
Mutations in GBA1 encoding the lysosomal enzyme β-glucocerebrosidase (GCase) are among the most prevalent genetic susceptibility factors for Parkinson's disease (PD), with 10-30% of carriers developing the disease. To identify...
3.
Menden K, Francescatto M, Nyima T, Blauwendraat C, Dhingra A, Castillo-Lizardo M, et al.
Sci Data
. 2023 Dec;
10(1):849.
PMID: 38040703
Understanding the molecular mechanisms underlying frontotemporal dementia (FTD) is essential for the development of successful therapies. Systematic studies on human post-mortem brain tissue of patients with genetic subtypes of FTD...
4.
Czuppa M, Dhingra A, Zhou Q, Schludi C, Konig L, Scharf E, et al.
Cell Rep
. 2022 Jun;
39(10):110913.
PMID: 35675776
An intronic (GC) expansion in C9orf72 causes amyotrophic lateral sclerosis and frontotemporal dementia primarily through gain-of-function mechanisms: the accumulation of sense and antisense repeat RNA foci and dipeptide repeat (DPR)...
5.
Heinzer D, Avar M, Pease D, Dhingra A, Yin J, Schaper E, et al.
PLoS Pathog
. 2021 Oct;
17(10):e1010013.
PMID: 34705895
The cellular prion protein PrPC is necessary for prion replication, and its reduction greatly increases life expectancy in animal models of prion infection. Hence the factors controlling the levels of...
6.
Strauss T, Marvian-Tayaranian A, Sadikoglou E, Dhingra A, Wegner F, Trumbach D, et al.
Front Cell Dev Biol
. 2021 Sep;
9:726866.
PMID: 34532319
The H1 haplotype of the microtubule-associated protein tau () gene is a common genetic risk factor for some neurodegenerative diseases such as progressive supranuclear palsy, corticobasal degeneration, and Parkinson's disease....
7.
Pal A, Kretner B, Abo-Rady M, GlaB H, Dash B, Naumann M, et al.
Life Sci Alliance
. 2021 Feb;
4(4).
PMID: 33619157
Intronic hexanucleotide repeat expansions (HREs) in are the most frequent genetic cause of amyotrophic lateral sclerosis, a devastating, incurable motoneuron (MN) disease. The mechanism by which HREs trigger pathogenesis remains...
8.
Dhingra A, Tager J, Bressan E, Rodriguez-Nieto S, Bedi M, Broer S, et al.
J Vis Exp
. 2020 Aug;
(162).
PMID: 32831313
Manual culture and differentiation protocols for human induced pluripotent stem cells (hiPSC) are difficult to standardize, show high variability and are prone to spontaneous differentiation into unwanted cell types. The...
9.
Rosa F, Dhingra A, Uysal B, Mendis G, Loeffler H, Elsen G, et al.
Stem Cell Reports
. 2020 Jun;
15(1):22-37.
PMID: 32559460
Neurons differentiated from induced pluripotent stem cells (iPSCs) typically show regular spiking and synaptic activity but lack more complex network activity critical for brain development, such as periodic depolarizations including...
10.
Seixas A, Loureiro J, Costa C, Ordonez-Ugalde A, Marcelino H, Oliveira C, et al.
Am J Hum Genet
. 2017 Jul;
101(1):87-103.
PMID: 28686858
Advances in human genetics in recent years have largely been driven by next-generation sequencing (NGS); however, the discovery of disease-related gene mutations has been biased toward the exome because the...