Ashley E Frakes
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Explore the profile of Ashley E Frakes including associated specialties, affiliations and a list of published articles.
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12
Citations
724
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Recent Articles
1.
Metcalf M, Monshietehadi S, Sahay A, Durieux J, Frakes A, Velichkovska M, et al.
iScience
. 2024 Mar;
27(4):109354.
PMID: 38500817
Glia are the protectors of the nervous system, providing neurons with support and protection from cytotoxic insults. We previously discovered that four astrocyte-like glia can regulate organismal proteostasis and longevity...
2.
Gildea H, Frankino P, Tronnes S, Pender C, Durieux J, Dishart J, et al.
Sci Adv
. 2022 Dec;
8(49):eabq3970.
PMID: 36490338
Aging organisms lose the ability to induce stress responses, becoming vulnerable to protein toxicity and tissue damage. Neurons can signal to peripheral tissues to induce protective organelle-specific stress responses. Recent...
3.
Ward C, Peng L, Yuen S, Halstead J, Palacios H, Nyangau E, et al.
Aging Cell
. 2022 Feb;
21(3):e13558.
PMID: 35170180
Age is a risk factor for numerous diseases, including neurodegenerative diseases, cancers, and diabetes. Loss of protein homeostasis is a central hallmark of aging. Activation of the endoplasmic reticulum unfolded...
4.
Ward C, Peng L, Yuen S, Chang M, Karapetyan R, Nyangau E, et al.
Int J Mol Sci
. 2022 Feb;
23(3).
PMID: 35162995
The unfolded protein response in the endoplasmic reticulum (UPR) is involved in a number of metabolic diseases. Here, we characterize UPR-induced metabolic changes in mouse livers in vivo through metabolic...
5.
Bar-Ziv R, Frakes A, Higuchi-Sanabria R, Bolas T, Frankino P, Gildea H, et al.
J Vis Exp
. 2020 Jun;
(159).
PMID: 32510480
Organisms are often exposed to fluctuating environments and changes in intracellular homeostasis, which can have detrimental effects on their proteome and physiology. Thus, organisms have evolved targeted and specific stress...
6.
Frakes A, Metcalf M, Tronnes S, Bar-Ziv R, Durieux J, Gildea H, et al.
Science
. 2020 Jan;
367(6476):436-440.
PMID: 31974253
The ability of the nervous system to sense cellular stress and coordinate protein homeostasis is essential for organismal health. Unfortunately, stress responses that mitigate disturbances in proteostasis, such as the...
7.
Frakes A, Dillin A
Mol Cell
. 2017 Jun;
66(6):761-771.
PMID: 28622521
Life is stressful. Organisms are repeatedly exposed to stressors that disrupt protein homeostasis (proteostasis), resulting in protein misfolding and aggregation. To sense and respond to proteotoxic perturbations, cells have evolved...
8.
Frakes A, Braun L, Ferraiuolo L, Guttridge D, Kaspar B
Ann Clin Transl Neurol
. 2017 Feb;
4(2):76-86.
PMID: 28168207
Objective: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which glia are central mediators of motor neuron (MN) death. Since multiple cell types are involved in disease pathogenesis,...
9.
Ahmed S, Schattgen S, Frakes A, Sikoglu E, Su Q, Li J, et al.
Mol Ther
. 2016 Apr;
24(6):1030-1041.
PMID: 27039844
Aspartoacylase (AspA) gene mutations cause the pediatric lethal neurodegenerative Canavan disease (CD). There is emerging promise of successful gene therapy for CD using recombinant adeno-associated viruses (rAAVs). Here, we report...
10.
Song S, Miranda C, Braun L, Meyer K, Frakes A, Ferraiuolo L, et al.
Nat Med
. 2016 Mar;
22(4):397-403.
PMID: 26928464
Astrocytes isolated from individuals with amyotrophic lateral sclerosis (ALS) are toxic to motor neurons (MNs) and play a non-cell autonomous role in disease pathogenesis. The mechanisms underlying the susceptibility of...