Ashish Radadiya
Overview
Explore the profile of Ashish Radadiya including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
160
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0
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Recent Articles
1.
Li W, Girt G, Radadiya A, Stewart J, Richards N, Naismith J
Open Biol
. 2023 Jan;
13(1):220287.
PMID: 36629016
The biosynthetic enzyme, ForT, catalyses the formation of a C-C bond between 4-amino-1-pyrazoledicarboxylic acid and MgPRPP to produce a C-nucleoside precursor of formycin A. The transformation catalysed by ForT is...
2.
Bijani S, Shaikh F, Mirza S, Siu S, Jain N, Rawal R, et al.
ACS Omega
. 2022 May;
7(19):16278-16287.
PMID: 35601326
P-glycoprotein (Pgp), an ATP binding cassette (ABC) transporter, is an ATP-dependent efflux pump responsible for cancer multidrug resistance. As part of efforts to identify human Pgp (hPgp) inhibitors, we prepared...
3.
Radadiya A, Zhu W, Coricello A, Alcaro S, Richards N
Biochemistry
. 2020 Aug;
59(35):3193-3200.
PMID: 32786406
l-Asparaginase (EC 3.5.1.1) was first used as a component of combination drug therapies to treat acute lymphoblastic leukemia (ALL), a cancer of the blood and bone marrow, almost 50 years...
4.
Gao S, Radadiya A, Li W, Liu H, Zhu W, de Crecy-Lagard V, et al.
Chem Commun (Camb)
. 2020 Jun;
56(55):7617-7620.
PMID: 32515440
The enzyme ForT catalyzes C-C bond formation between 5'-phosphoribosyl-1'-pyrophosphate (PRPP) and 4-amino-1H-pyrazole-3,5-dicarboxylate to make a key intermediate in the biosynthesis of formycin A 5'-phosphate by Streptomyces kaniharaensis. We report the...
5.
Radadiya A, Pickett J
Philos Trans R Soc Lond B Biol Sci
. 2020 Apr;
375(1800):20190263.
PMID: 32306882
Interactions relating to human chemical signalling, although widely acknowledged, are relatively poorly characterized chemically, except for human axillary odour. However, the extensive chemical ecology of insects, involving countless pheromone and...
6.
Eberlein L, Beierlein F, van Eikema Hommes N, Radadiya A, Heil J, Benner S, et al.
J Chem Theory Comput
. 2020 Mar;
16(4):2766-2777.
PMID: 32125859
Evolution has yielded biopolymers that are constructed from exactly four building blocks and are able to support Darwinian evolution. Synthetic biology aims to extend this alphabet, and we recently showed...
7.
Zhu W, Radadiya A, Bisson C, Wenzel S, Nordin B, Martinez-Marquez F, et al.
Commun Biol
. 2019 Dec;
2:438.
PMID: 31799439
[This corrects the article DOI: 10.1038/s42003-019-0587-z.].
8.
Zhu W, Radadiya A, Bisson C, Wenzel S, Nordin B, Martinez-Marquez F, et al.
Commun Biol
. 2019 Sep;
2:345.
PMID: 31552298
Expression of human asparagine synthetase (ASNS) promotes metastatic progression and tumor cell invasiveness in colorectal and breast cancer, presumably by altering cellular levels of L-asparagine. Human ASNS is therefore emerging...
9.
Athar M, Lone M, Khedkar V, Radadiya A, Shah A, Jha P
Comb Chem High Throughput Screen
. 2017 May;
20(8):682-695.
PMID: 28486912
Aim And Objective: Vinca domain of tubulin protein is the potential target for different microtubule targeting drugs (MTD). However, its binding mechanism and structure-activityrelationship (SAR) is not well understood in...
10.
Patel S, Shaikh F, Devaraji V, Radadiya A, Shah K, Shah A, et al.
J Biomol Struct Dyn
. 2016 Jan;
35(2):354-367.
PMID: 26766750
Transient interactions between cancer stem cells and components of the tumor microenvironment initiate various signaling pathways crucial for carcinogenesis. Predominant hyaluronan (HA) receptor, CD44 is structurally and functionally one of...