Arun Samidurai
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Explore the profile of Arun Samidurai including associated specialties, affiliations and a list of published articles.
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28
Citations
521
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Recent Articles
11.
Samidurai A, Ockaili R, Cain C, Roh S, Filippone S, Kraskauskas D, et al.
iScience
. 2020 Dec;
23(12):101863.
PMID: 33319180
Persistent activation of mTOR (mammalian target of rapamycin) in diabetes increases the vulnerability of the heart to ischemia/reperfusion (I/R) injury. We show here that infusion of rapamycin (mTOR inhibitor) at...
12.
Samidurai A, Das A
Int J Mol Sci
. 2020 Sep;
21(18).
PMID: 32947927
The outbreak of coronavirus disease 2019 (COVID-19), an infectious disease with severe acute respiratory syndrome, has now become a worldwide pandemic. Despite the respiratory complication, COVID-19 is also associated with...
13.
Gertz Z, Cain C, Kraskauskas D, Devarakonda T, Mauro A, Thompson J, et al.
JACC CardioOncol
. 2020 Jul;
1(2):221-234.
PMID: 32699841
Objectives: Because of its multifaceted cardioprotective effects, remote ischemic pre-conditioning (RIPC) was examined as a strategy to attenuate doxorubicin (DOX) cardiotoxicity. Background: The use of DOX is limited by dose-dependent...
14.
Chen Q, Samidurai A, Thompson J, Hu Y, Das A, Willard B, et al.
Biochim Biophys Acta Mol Basis Dis
. 2020 Jul;
1866(11):165899.
PMID: 32698045
Aging impairs the mitochondrial electron transport chain (ETC), especially in interfibrillar mitochondria (IFM). Mitochondria are in close contact with the endoplasmic reticulum (ER). Induction of ER stress leads to ETC...
15.
Samidurai A, Xi L, Salloum F, Das A, Kukreja R
Mol Cell Biochem
. 2020 Jun;
471(1-2):189-201.
PMID: 32535704
Abusive chronic alcohol consumption can cause metabolic and functional derangements in the heart and is a risk factor for development of non-ischemic cardiomyopathy. microRNA 214 (miR-214) is a molecular sensor...
16.
Samidurai A, Roh S, Prakash M, Durrant D, Salloum F, Kukreja R, et al.
Cardiovasc Res
. 2019 Nov;
116(13):2103-2115.
PMID: 31738412
Aims: Deregulation of mTOR (mammalian target of rapamycin) signalling occurs in diabetes, which exacerbates injury following myocardial infarction (MI). We therefore investigated the infarct-limiting effect of chronic treatment with rapamycin...
17.
Mohsin A, Chen Q, Quan N, Rousselle T, Maceyka M, Samidurai A, et al.
J Pharmacol Exp Ther
. 2019 Mar;
369(2):282-290.
PMID: 30846619
Transient, reversible blockade of complex I during early reperfusion after ischemia limits cardiac injury. We studied the cardioprotection of high dose of metformin in cultured cells and mouse hearts via...
18.
Samidurai A, Kukreja R, Das A
Oxid Med Cell Longev
. 2018 Oct;
2018:6141902.
PMID: 30305865
Mechanistic/mammalian target of rapamycin (mTOR), an atypical serine/threonine kinase of the phosphoinositide 3-kinase- (PI3K-) related kinase family, elicits a vital role in diverse cellular processes, including cellular growth, proliferation, survival,...
19.
Das A, Samidurai A, Salloum F
Front Cardiovasc Med
. 2018 Jul;
5:73.
PMID: 30013975
After being long considered as "junk" in the human genome, non-coding RNAs (ncRNAs) currently represent one of the newest frontiers in cardiovascular disease (CVD) since they have emerged in recent...
20.
Samidurai A, Salloum F, Durrant D, Chernova O, Kukreja R, Das A
Br J Pharmacol
. 2017 Oct;
174(24):4771-4784.
PMID: 28967097
Background And Purpose: Enhanced mammalian target of rapamycin (mTOR) signalling contributes to the pathogenesis of diabetes and plays a critical role in myocardial ischaemia/reperfusion (I/R) injury. Rapatar is a novel...