Arun Kumar Kondadi
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Explore the profile of Arun Kumar Kondadi including associated specialties, affiliations and a list of published articles.
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21
Citations
508
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Recent Articles
1.
Naha R, Strohm R, Schaumkessel Y, Urbach J, Wittig I, Reichert A, et al.
iScience
. 2024 Dec;
27(12):111467.
PMID: 39720525
The MICOS complex, essential for cristae organization, comprises MIC10 and MIC60 subcomplexes, with MIC13 as a crucial subunit. mutations cause severe mitochondrial hepato-encephalopathy, cristae defects, and MIC10-subcomplex loss. We demonstrate...
2.
Mitochondrial apolipoprotein MIC26 is a metabolic rheostat regulating central cellular fuel pathways
Damiecki M, Naha R, Schaumkessel Y, Westhoff P, Atanelov N, Stefanski A, et al.
Life Sci Alliance
. 2024 Oct;
7(12).
PMID: 39393820
Mitochondria play central roles in metabolism and metabolic disorders such as type 2 diabetes. MIC26, a mitochondrial contact site and cristae organising system complex subunit, was linked to diabetes and...
3.
Kondadi A, Reichert A
Annu Rev Biophys
. 2024 Jan;
53(1):147-168.
PMID: 38166176
Mitochondria are essential organelles performing important cellular functions ranging from bioenergetics and metabolism to apoptotic signaling and immune responses. They are highly dynamic at different structural and functional levels. Mitochondria...
4.
Golombek M, Tsigaras T, Schaumkessel Y, Hansch S, Weidtkamp-Peters S, Anand R, et al.
Life Sci Alliance
. 2023 Nov;
7(2).
PMID: 37957016
Cristae membranes have been recently shown to undergo intramitochondrial merging and splitting events. Yet, the metabolic and bioenergetic factors regulating them are unclear. Here, we investigated whether and how cristae...
5.
Jochims F, Strohm R, von Montfort C, Wenzel C, Klahm N, Kondadi A, et al.
Biomedicines
. 2023 Sep;
11(9).
PMID: 37760834
Despite great efforts to develop new therapeutic strategies to combat melanoma, the prognosis remains rather poor. Artesunate (ART) is an antimalarial drug displaying anti-cancer effects in vitro and in vivo....
6.
Peifer-Weiss L, Kurban M, David C, Lubeck M, Kondadi A, Nemer G, et al.
Clin Genet
. 2023 Aug;
104(6):659-668.
PMID: 37649161
APOO/MIC26 is a subunit of the MICOS complex required for mitochondrial cristae morphology and function. Here, we report a novel variant of the APOO/MIC26 gene that causes a severe mitochondrial...
7.
Molinari P, Krapp A, Weiner A, Beyer H, Kondadi A, Blomeier T, et al.
Nat Commun
. 2023 Jun;
14(1):3277.
PMID: 37280202
NADP(H) is a central metabolic hub providing reducing equivalents to multiple biosynthetic, regulatory and antioxidative pathways in all living organisms. While biosensors are available to determine NADP or NADPH levels...
8.
Lubeck M, Derkum N, Naha R, Strohm R, Driessen M, Belgardt B, et al.
PLoS One
. 2023 Jun;
18(6):e0286756.
PMID: 37279200
Impairments of mitochondrial functions are linked to human ageing and pathologies such as cancer, cardiomyopathy, neurodegeneration and diabetes. Specifically, aberrations in ultrastructure of mitochondrial inner membrane (IM) and factors regulating...
9.
Haasler L, von Montfort C, Kondadi A, Golombek M, Ebbert L, Wenzel C, et al.
Arch Toxicol
. 2023 May;
97(7):1997-2014.
PMID: 37210688
Cutaneous basal and squamous cell carcinoma reflect the first and second most common type of non-melanoma skin cancer, respectively. Especially cutaneous squamous cell carcinoma has the tendency to metastasize, finally...
10.
Griess K, Rieck M, Muller N, Karsai G, Hartwig S, Pelligra A, et al.
Nat Cell Biol
. 2022 Dec;
25(1):20-29.
PMID: 36543979
Impaired proinsulin-to-insulin processing in pancreatic β-cells is a key defective step in both type 1 diabetes and type 2 diabetes (T2D) (refs. ), but the mechanisms involved remain to be...