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Arnold Z Olali

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Recent Articles
1.
Yardeni T, Olali A, Chen H, Wang L, Halton J, Zenab A, et al.
Proc Natl Acad Sci U S A . 2025 Jan; 122(1):e2417252121. PMID: 39752523
Mitochondrial DNA (mtDNA) is highly polymorphic, and host mtDNA variation has been associated with altered cancer severity. To determine the basis of this mtDNA-cancer association, we analyzed conplastic mice with...
2.
Topper M, Guarnieri J, Haltom J, Chadburn A, Cope H, Frere J, et al.
Proc Natl Acad Sci U S A . 2024 Nov; 121(49):e2401968121. PMID: 39602262
Lethal COVID-19 outcomes are attributed to classic cytokine storm. We revisit this using RNA sequencing of nasopharyngeal and 40 autopsy samples from patients dying of SARS-CoV-2. Subsets of the 100...
3.
Guarnieri J, Haltom J, Soto Albrecht Y, Lie T, Olali A, Widjaja G, et al.
Pharmacol Res . 2024 Apr; 204:107170. PMID: 38614374
To determine the effects of SARS-CoV-2 infection on cellular metabolism, we conducted an exhaustive survey of the cellular metabolic pathways modulated by SARS-CoV-2 infection and confirmed their importance for SARS-CoV-2...
4.
Olali A, Wallace J, Gonzalez H, Carpenter K, Patel N, Winchester L, et al.
JBMR Plus . 2024 Apr; 8(5):ziae037. PMID: 38590756
Bone mineral density (BMD) loss in people living with HIV occurs with the initiation of combined antiretroviral therapy (cART), particularly with tenofovir disoproxil fumarate (TDF) containing cART. Switching from TDF...
5.
Virdi A, Ho S, Seaton M, Olali A, Narasipura S, Barbian H, et al.
Cells . 2023 Apr; 12(7). PMID: 37048107
HIV anti-retrovirals (ARVs) have vastly improved the life expectancy of people living with HIV (PLWH). However, toxic effects attributed to long-term ARV use also contribute to HIV-related co-morbidities such as...
6.
Ross R, Olali A, Shi Q, Hoover D, Sharma A, Weber K, et al.
J Acquir Immune Defic Syndr . 2022 Sep; 91(2):162-167. PMID: 36094482
Introduction: Bone loss and cognitive impairment are common in women living with HIV (WLWH) and are exacerbated by menopause. Bone-derived undercarboxylated osteocalcin (ucOCN) and sclerostin appear to influence cognition. The...
7.
Olali A, Carpenter K, Myers M, Sharma A, Yin M, Al-Harthi L, et al.
Curr HIV/AIDS Rep . 2022 Jun; 19(5):312-327. PMID: 35726043
Purpose Of Review: People living with HIV (PLWH) are at an increased risk for osteoporosis, a disease defined by the loss of bone mineral density (BMD) and deterioration of bone...
8.
Wallace J, Gonzalez H, Rajan R, Narasipura S, Virdi A, Olali A, et al.
Antimicrob Agents Chemother . 2022 Mar; 66(4):e0194121. PMID: 35293780
Combination antiretroviral therapy (cART) dramatically changed the face of the HIV/AIDS pandemic, making it one of the most prominent medical breakthroughs of the past 3 decades. However, as the life...
9.
Olali A, Shi Q, Hoover D, Bucovsky M, Shane E, Yin M, et al.
Bone . 2021 Sep; 154:116208. PMID: 34547525
Background: Bone mineral density (BMD) loss and fat gain is common in people living with HIV (PLWH), particularly after initiating combination antiretroviral therapy (cART). Given the close metabolic interaction between...
10.
Olali A, Sharma A, Shi Q, Hoover D, Weber K, French A, et al.
J Acquir Immune Defic Syndr . 2021 Jan; 86(5):e139-e145. PMID: 33399313
Background: Bone mineral density loss and fat accumulation are common in people living with HIV. The bone-derived hormone, undercarboxylated osteocalcin (ucOCN) regulates fat metabolism. We investigated the relationship between ucOCN...