Arkadiusz Leniak
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Explore the profile of Arkadiusz Leniak including associated specialties, affiliations and a list of published articles.
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10
Citations
16
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Recent Articles
1.
From NMR to AI: Do We Need H NMR Experimental Spectra to Obtain High-Quality logD Prediction Models?
Leniak A, Pietrus W, Swiderska A, Kurczab R
J Chem Inf Model
. 2025 Mar;
PMID: 40044424
This study presents a novel approach to H NMR-based machine learning (ML) models for predicting logD using computer-generated H NMR spectra. Building on our previous work, which integrated experimental H...
2.
Leniak A, Pietrus W, Kurczab R
J Chem Inf Model
. 2024 Mar;
64(8):3302-3321.
PMID: 38529877
A novel approach to the utilization of nuclear magnetic resonance (NMR) spectroscopy data in the prediction of logD through machine learning algorithms is shown. In the analysis, a data set...
3.
Szczepanska K, Karcz T, Dichiara M, Mogilski S, Kalinowska-Tluscik J, Pilarski B, et al.
J Med Chem
. 2023 Jul;
66(14):9658-9683.
PMID: 37418295
In search of new dual-acting histamine H/sigma-1 receptor ligands, we designed a series of compounds structurally based on highly active ligands previously studied and described by our team. However, we...
4.
Pietrus W, Stypik M, Zagozda M, Banach M, Gurba-Bryskiewicz L, Maruszak W, et al.
Molecules
. 2023 Apr;
28(8).
PMID: 37110764
As a member of the class I PI3K family, phosphoinositide 3-kinase (PI3K) is an important signaling biomolecule that controls immune cell differentiation, proliferation, migration, and survival. It also represents a...
5.
Stypik M, Zagozda M, Michalek S, Dymek B, Zdzalik-Bielecka D, Dziachan M, et al.
Pharmaceuticals (Basel)
. 2022 Aug;
15(8).
PMID: 36015098
Phosphoinositide 3-kinase (PI3K), a member of the class I PI3K family, is an essential signaling biomolecule that regulates the differentiation, proliferation, migration, and survival of immune cells. The overactivity of...
6.
Stypik M, Michalek S, Orlowska N, Zagozda M, Dziachan M, Banach M, et al.
Pharmaceuticals (Basel)
. 2022 Aug;
15(8).
PMID: 36015075
Phosphoinositide 3-kinase (PI3K) is the family of lipid kinases participating in vital cellular processes such as cell proliferation, growth, migration, or cytokines production. Due to the high expression of these...
7.
Weclawski M, Deperasinska I, Banasiewicz M, Young D, Leniak A, Gryko D
Chem Asian J
. 2018 Jul;
14(10):1763-1770.
PMID: 30022613
The double Knoevenagel condensation of 1,4-dibenzoyloxyanthraquinone with methyl esters of arylacetic acids affords a series of compounds based upon a previously unknown 1,8-dioxa-benzo[e]pyrene-2,7-dione heterocyclic core. The aryl groups incorporated in...
8.
Szwarc K, Plosinski M, Czerniejewska K, Laskowski T, Leniak A, Czub J, et al.
Magn Reson Chem
. 2016 Jul;
54(12):953-961.
PMID: 27379602
Nystatin A , a polyene macrolide antifungal antibiotic, in a slightly basic or acidic solution undergoes an intramolecular transformation, yielding a structural isomer, the translactonization product, iso-nystatin A with lactone...
9.
Weclawski M, Deperasinska I, Leniak A, Banasiewicz M, Kozankiewicz B, Gryko D
Org Biomol Chem
. 2016 Jul;
14(29):7046-52.
PMID: 27367169
New synthetic methods leading towards π-expanded heterocycles are sought after mainly due to their promising opto-electronic properties. Subjecting 1,5,9,10-tetramethoxyanthracene to the modern Duff reaction conditions led to the formation of...
10.
Weclawski M, Meiling T, Leniak A, Cywinski P, Gryko D
Org Lett
. 2015 Aug;
17(17):4252-5.
PMID: 26313364
Previously unknown, vertically linked heterocycles comprised of benzofuran and iminocoumarin moieties have been synthesized directly from 1,5-dibenzoyloxyanthraquinone and arylacetonitriles via double Knoevenagel condensation followed by formal HCN elimination. The structural...