Lidia Gurba-Bryskiewicz
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Explore the profile of Lidia Gurba-Bryskiewicz including associated specialties, affiliations and a list of published articles.
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10
Citations
35
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Recent Articles
1.
Michalek S, Maj A, Gurba-Bryskiewicz L, Maruszak W, Wisniewski K, Zagozda M, et al.
RSC Adv
. 2024 Sep;
14(39):28516-28523.
PMID: 39247513
Herein, we describe a two-step sequential flow synthesis: Pd-catalyzed aerobic oxidation to an aldehyde 2, which is then converted by reductive amination in H-Cube® PRO into CPL302415 (3). CPL302415 is...
2.
Gurba-Bryskiewicz L, Maruszak W, Smuga D, Dubiel K, Wieczorek M
Biomedicines
. 2023 Oct;
11(10).
PMID: 37893125
The successful development of nonviral delivery systems for nucleic acids has been reported extensively over the past years. Increasingly employed to improve the delivery efficiency and therapeutic efficacy of RNA...
3.
Pietrus W, Stypik M, Zagozda M, Banach M, Gurba-Bryskiewicz L, Maruszak W, et al.
Molecules
. 2023 Apr;
28(8).
PMID: 37110764
As a member of the class I PI3K family, phosphoinositide 3-kinase (PI3K) is an important signaling biomolecule that controls immune cell differentiation, proliferation, migration, and survival. It also represents a...
4.
Michalek S, Gurba-Bryskiewicz L, Maruszak W, Zagozda M, Maj A, Ochal Z, et al.
RSC Adv
. 2022 Dec;
12(52):33605-33611.
PMID: 36505705
Herein, we describe the development of a green, scalable flow Pd-catalyzed aerobic oxidation for the key step in the synthesis of CPL302415, which is a new PI3K inhibitor. Applying this...
5.
Gurba-Bryskiewicz L, Dawid U, Smuga D, Maruszak W, Delis M, Szymczak K, et al.
Int J Mol Sci
. 2022 Sep;
23(18).
PMID: 36142622
The purpose of this work was to demonstrate the use of the AQbD with the DOE approach to the methodical step-by-step development of a UHPLC method for the quantitative determination...
6.
Stypik M, Zagozda M, Michalek S, Dymek B, Zdzalik-Bielecka D, Dziachan M, et al.
Pharmaceuticals (Basel)
. 2022 Aug;
15(8).
PMID: 36015098
Phosphoinositide 3-kinase (PI3K), a member of the class I PI3K family, is an essential signaling biomolecule that regulates the differentiation, proliferation, migration, and survival of immune cells. The overactivity of...
7.
Stypik M, Michalek S, Orlowska N, Zagozda M, Dziachan M, Banach M, et al.
Pharmaceuticals (Basel)
. 2022 Aug;
15(8).
PMID: 36015075
Phosphoinositide 3-kinase (PI3K) is the family of lipid kinases participating in vital cellular processes such as cell proliferation, growth, migration, or cytokines production. Due to the high expression of these...
8.
Bukowska-Olech E, Sowinska-Seidler A, Larysz D, Gawlinski P, Koczyk G, Popiel D, et al.
Front Mol Biosci
. 2022 May;
9:865494.
PMID: 35591945
Craniosynostosis (CS) represents a highly heterogeneous genetic condition whose genetic background has not been yet revealed. The abnormality occurs either in isolated form or syndromic, as an element of hundreds...
9.
Mach M, Bazydlo-Guzenda K, Buda P, Matloka M, Dzida R, Stelmach F, et al.
Eur J Med Chem
. 2021 Sep;
226:113810.
PMID: 34537444
Due to a unique mechanism that limits the possibility of hypoglycemia, the free fatty acid receptor (FFA1) is an attractive target for the treatment of type 2 diabetes. So far,...
10.
Pankiewicz P, Szybinski M, Kisielewska K, Golebiowski F, Krzeminski P, Rutkowska-Wlodarczyk I, et al.
Pharmaceuticals (Basel)
. 2021 Aug;
14(8).
PMID: 34451801
TrkB is a tyrosine kinase receptor that is activated upon binding to brain-derived neurotrophic factor (BDNF). To date, the search for low-molecular-weight molecules mimicking BDNF's action has been unsuccessful. Several...