Arjun Kalvala
Overview
Explore the profile of Arjun Kalvala including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
119
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Recent Articles
1.
Duan W, Tang S, Gao L, Dotts K, Fink A, Kalvala A, et al.
Sci Rep
. 2021 Feb;
11(1):4420.
PMID: 33627769
The Fanconi Anemia (FA) pathway is essential for human cells to maintain genomic integrity following DNA damage. This pathway is involved in repairing damaged DNA through homologous recombination. Cancers with...
2.
Kalvala A, Wallet P, Yang L, Wang C, Li H, Nam A, et al.
J Clin Med
. 2019 Oct;
8(10).
PMID: 31635338
Oncogenic (mutant) Ras protein Kirsten rat sarcoma viral oncogene homolog (KRAS) promotes uncontrolled proliferation, altered metabolism, and loss of genome integrity in a cell-intrinsic manner. Here, we demonstrate that CD4...
3.
Duan W, Gao L, Kalvala A, Aguila B, Brooks C, Mo X, et al.
Int J Cancer
. 2019 Mar;
145(9):2418-2426.
PMID: 30873587
TP53 and K-ras mutations are two of the major genetic alterations in human nonsmall cell lung cancers. The association between these two genes during lung tumorigenesis is unknown. We evaluated...
4.
Truong Nguyen L, Troadec E, Kalvala A, Kumar B, Hoang D, Viola D, et al.
J Cell Physiol
. 2019 Jan;
234(8):14040-14049.
PMID: 30623427
Induction of reactive oxygen species (ROS), an important process for the cytotoxicity of various acute myeloid leukemia (AML) therapies including hypomethylating agents (HMAs), concurrently activates the NF-E2-related factor 2 (Nrf2)...
5.
Kumar B, Kalvala A, Chu S, Rosen S, Forman S, Marcucci G, et al.
Leuk Res
. 2017 Jun;
59:124-135.
PMID: 28646646
The artimisinins are a class of antimalarial compounds whose antiparasitic activity is mediated by induction of reactive oxygen species (ROS). Herein, we report that among the artimisinins, artesunate (ARTS), an...
6.
Kalvala A, Gao L, Aguila B, Dotts K, Rahman M, Nana-Sinkam S, et al.
Mol Cancer
. 2016 Jun;
15(1):47.
PMID: 27296891
Background: Fusion proteins have unique oncogenic properties and their identification can be useful either as diagnostic or therapeutic targets. Next generation sequencing data have previously shown a fusion gene formed...
7.
Kalvala A, Gao L, Aguila B, Reese T, Otterson G, Villalona-Calero M, et al.
Oncotarget
. 2015 Feb;
6(11):8777-87.
PMID: 25669972
Functional alterations in Rad51C are the cause of the Fanconi anemia complementation group O (FANCO) gene disorder. We have identified novel splice variants of Rad51C mRNA in colorectal tumors and...
8.
Duan W, Gao L, Aguila B, Kalvala A, Otterson G, Villalona-Calero M
Front Oncol
. 2015 Jan;
4:368.
PMID: 25566506
The Fanconi anemia (FA) pathway is a major mechanism of homologous recombination DNA repair. The functional readout of the pathway is activation through mono-ubiquitination of FANCD2 leading to nuclear foci...
9.
Kalvala A, Rainaldi G, Di Primio C, Liverani V, Falaschi A, Galli A
Nucleic Acids Res
. 2010 Jun;
38(14):e149.
PMID: 20519199
The introduction of exogenous DNA in human somatic cells results in a frequency of random integration at least 100-fold higher than gene targeting (GT), posing a seemingly insurmountable limitation for...