Ariel R Topletz
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Explore the profile of Ariel R Topletz including associated specialties, affiliations and a list of published articles.
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10
Citations
277
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Recent Articles
1.
Topletz A, Zhong G, Isoherranen N
Sci Rep
. 2019 Mar;
9(1):4620.
PMID: 30874620
All-trans-retinoic acid (atRA), the active metabolite of vitamin A, is a critical signaling molecule during embryonic and fetal development and is necessary for maternal health. Fetal exposure to endogenous atRA...
2.
Jing J, Petroff R, Shum S, Crouthamel B, Topletz A, Grant K, et al.
Drug Metab Dispos
. 2017 Nov;
46(2):155-165.
PMID: 29150543
Domoic acid (DA), a neurotoxin, is produced by marine algae and has caused toxications worldwide in animals and humans. However, the toxicokinetics of DA have not been fully evaluated, and...
3.
Jamwal R, Topletz A, Ramratnam B, Akhlaghi F
J Chromatogr B Analyt Technol Biomed Life Sci
. 2017 Feb;
1048:10-18.
PMID: 28192758
Cannabis is used widely in the United States, both recreationally and for medical purposes. Current methods for analysis of cannabinoids in human biological specimens rely on complex extraction process and...
4.
Topletz A, Tripathy S, Foti R, Shimshoni J, Nelson W, Isoherranen N
Mol Pharmacol
. 2014 Dec;
87(3):430-41.
PMID: 25492813
All-trans-retinoic acid (atRA), the active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs). The primary hydroxylated metabolites formed from atRA by CYP26A1, and...
5.
Lehmann A, Renbarger J, McCormick C, Topletz A, Rouse C, Haas D
BMC Pregnancy Childbirth
. 2013 Jun;
13:132.
PMID: 23786674
Background: Nausea and vomiting of pregnancy (NVP) is a common condition. The objective of this study was to evaluate the association between response to antiemetics in the treatment of NVP...
6.
Topletz A, Dennison J, Barbuch R, Hadden C, Hall S, Renbarger J
Drug Metab Dispos
. 2013 Jun;
41(9):1651-61.
PMID: 23780963
Vinorelbine is a semisynthetic vinca alkaloid used in the treatment of advanced breast and non-small cell lung cancers. Vincristine, a related vinca alkaloid, is 9-fold more efficiently metabolized by CYP3A5...
7.
Topletz A, Le H, Lee N, Chapman J, Kelly E, Wang J, et al.
Drug Metab Dispos
. 2012 Nov;
41(2):312-9.
PMID: 23150428
There is considerable evidence that drug disposition is altered during human pregnancy and based on probe drug studies, CYP2D6 activity increases during human pregnancy. The aim of this study was...
8.
Shimshoni J, Roberts A, Scian M, Topletz A, Blankert S, Halpert J, et al.
J Biol Chem
. 2012 Oct;
287(50):42223-32.
PMID: 23071109
All-trans-retinoic acid (atRA), the major active metabolite of vitamin A, plays a role in many biological processes, including maintenance of epithelia, immunity, and fertility and regulation of apoptosis and cell...
9.
Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases
Topletz A, Thatcher J, Zelter A, Lutz J, Tay S, Nelson W, et al.
Biochem Pharmacol
. 2011 Oct;
83(1):149-63.
PMID: 22020119
All-trans-retinoic acid (atRA) is an important signaling molecule in all chordates. The cytochrome P450 enzymes CYP26 are believed to partially regulate cellular concentrations of atRA via oxidative metabolism and hence...
10.
Egbelakin A, Ferguson M, MacGill E, Lehmann A, Topletz A, Quinney S, et al.
Pediatr Blood Cancer
. 2011 Jan;
56(3):361-7.
PMID: 21225912
Background: This study evaluates the relationship between cytochrome P450 (CYP) 3A5 genotype and vincristine-induced peripheral neuropathy (VIPN) in children with precursor B cell acute lymphoblastic leukemia (preB ALL). We have...