Ariel Gershman
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Explore the profile of Ariel Gershman including associated specialties, affiliations and a list of published articles.
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15
Citations
2303
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Recent Articles
1.
Mazzone P, Bach P, Carey J, Schonewolf C, Bognar K, Ahluwalia M, et al.
Cancer Discov
. 2024 Jun;
14(11):2224-2242.
PMID: 38829053
Lung cancer screening via annual low-dose computed tomography has poor adoption. We conducted a prospective case-control study among 958 individuals eligible for lung cancer screening to develop a blood-based lung...
2.
Rhie A, Nurk S, Cechova M, Hoyt S, Taylor D, Altemose N, et al.
Nature
. 2023 Aug;
621(7978):344-354.
PMID: 37612512
The human Y chromosome has been notoriously difficult to sequence and assemble because of its complex repeat structure that includes long palindromes, tandem repeats and segmental duplications. As a result,...
3.
Gershman A, Hauck Q, Dick M, Jamison J, Tassia M, Agirrezabala X, et al.
Genome Res
. 2023 May;
33(5):703-714.
PMID: 37156619
Hummingbirds are very well adapted to sustain efficient and rapid metabolic shifts. They oxidize ingested nectar to directly fuel flight when foraging but have to switch to oxidizing stored lipids...
4.
Hoyt S, Storer J, Hartley G, Grady P, Gershman A, Lima L, et al.
Science
. 2022 Mar;
376(6588):eabk3112.
PMID: 35357925
Mobile elements and repetitive genomic regions are sources of lineage-specific genomic innovation and uniquely fingerprint individual genomes. Comprehensive analyses of such repeat elements, including those found in more complex regions...
5.
Nurk S, Koren S, Rhie A, Rautiainen M, Bzikadze A, Mikheenko A, et al.
Science
. 2022 Mar;
376(6588):44-53.
PMID: 35357919
Since its initial release in 2000, the human reference genome has covered only the euchromatic fraction of the genome, leaving important heterochromatic regions unfinished. Addressing the remaining 8% of the...
6.
Vollger M, Guitart X, Dishuck P, Mercuri L, Harvey W, Gershman A, et al.
Science
. 2022 Mar;
376(6588):eabj6965.
PMID: 35357917
Despite their importance in disease and evolution, highly identical segmental duplications (SDs) are among the last regions of the human reference genome (GRCh38) to be fully sequenced. Using a complete...
7.
Gershman A, Sauria M, Guitart X, Vollger M, Hook P, Hoyt S, et al.
Science
. 2022 Mar;
376(6588):eabj5089.
PMID: 35357915
The completion of a telomere-to-telomere human reference genome, T2T-CHM13, has resolved complex regions of the genome, including repetitive and homologous regions. Here, we present a high-resolution epigenetic study of previously...
8.
Altemose N, Logsdon G, Bzikadze A, Sidhwani P, Langley S, Caldas G, et al.
Science
. 2022 Mar;
376(6588):eabl4178.
PMID: 35357911
Existing human genome assemblies have almost entirely excluded repetitive sequences within and near centromeres, limiting our understanding of their organization, evolution, and functions, which include facilitating proper chromosome segregation. Now,...
9.
Sholes S, Karimian K, Gershman A, Kelly T, Timp W, Greider C
Genome Res
. 2021 Oct;
32(4):616-628.
PMID: 34702734
We developed a method to tag telomeres and measure telomere length by nanopore sequencing in the yeast Nanopore allows long-read sequencing through the telomere, through the subtelomere, and into unique...
10.
Clark H, McKenney C, Livingston N, Gershman A, Sajjan S, Chan I, et al.
Nat Commun
. 2021 Mar;
12(1):1836.
PMID: 33758175
To prevent damage to the host or its commensal microbiota, epithelial tissues must match the intensity of the immune response to the severity of a biological threat. Toll-like receptors allow...